Keio University · Medicine
Professor Masaru Mimura's research lab specializes in cognitive neuroscience and neurolinguistics, focusing on the neural mechanisms underlying language recovery after stroke and the cognitive deficits associated with brain injury. The lab investigates how cerebral blood flow changes correlate with post-stroke aphasia recovery using neuroimaging techniques such as SPECT, and explores time perception and memory impairments in patients with frontal lobe damage or Korsakoff’s syndrome. A central theme is understanding the interplay between working memory, episodic memory, and temporal cognition in neurological disorders. The lab combines clinical assessments with advanced neuroimaging to uncover brain-behavior relationships in patients with acquired brain injuries.
Figures are computed from collected data and may differ slightly.
Prospective and retrospective language evaluations and single photon emission computed tomography (SPECT) scans were performed in order to study the relationship between post-stroke recovery from aphasia and changes in cerebral blood flow (CBF) in groups of patients who had made a good recovery and those who had not. For the prospective study, 20 right-handed patients with aphasia secondary to an acute cerebrovascular accident (CVA) in the left middle cerebral artery territory received language
We studied time estimation in patients with frontal damage (F) and alcoholic Korsakoff (K) patients in order to differentiate between the contributions of working memory and episodic memory to temporal cognition. In Experiment 1, F and K patients estimated time intervals between 10 and 120 s less accurately than matched normal and alcoholic control subjects. F patients were less accurate than K patients at short (< 1 min) time intervals whereas K patients increasingly underestimated durations as
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