The University of Tokyo · Medicine
Professor Masashi Fukayama's research lab focuses on the molecular and pathological mechanisms underlying gastrointestinal and soft tissue neoplasms, with a particular emphasis on Epstein-Barr virus (EBV)-associated gastric cancer, gastrointestinal stromal tumors (GISTs) in neurofibromatosis type 1, and the role of oncofetal markers such as SALL4 and AFP in gastric carcinogenesis. The lab integrates histopathology, immunohistochemistry, and molecular genetics to identify diagnostic and prognostic biomarkers, especially in rare and aggressive tumor subtypes. Their work contributes to early detection, risk stratification, and the development of targeted therapies for gastrointestinal malignancies.
Figures are computed from collected data and may differ slightly.
EBV may infect the surface epithelium of the stomach through the reactivated EBV-carrying lymphocytes. EBV may be a factor initiating EBVaGC. Anti-EBV antibodies or EBER1 in situ hybridization may help to identify patients at high risk for EBVaGC.
Gastrointestinal stromal tumor (GIST), as well as the hyperplastic lesions of intestinal neural tissue and its supporting structures, is a gastrointestinal complication of type 1 neurofibromatosis (NF1) (von Recklinghausen's disease). In the present study, we analyzed the histologic and immunohistochemical features, and the c-kit and PDGFRA gene mutations of 36 GISTs derived from 9 NF1 patients. Distinctively, multiple GISTs arose preferentially in the small intestine. The histologic features of
The novel stem cell marker SALL4 has been identified as a diagnostic marker of germ cell tumors, especially yolk sac tumors, in gonadal organs. To clarify the significance of SALL4 as an oncofetal protein, we investigated SALL4 expression by immunohistochemistry in non-neoplastic stomach and gastric carcinoma with particular emphasis on á-fetoprotein (AFP)-producing gastric carcinoma, as AFP-producing gastric carcinoma shares expression of AFP and glypican 3 (GPC3) with yolk sac tumors and hepat
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