The University of Osaka · Medicine
Professor Md Sayeedul Islam's research lab focuses on computational and systems biology approaches to address pressing challenges in health and agriculture. The lab specializes in bioinformatics, phytochemical database development, and structure-based drug design, particularly targeting viral proteases like those of SARS-CoV-2 and influenza A. It also investigates plant stress responses, with recent work exploring the role of hydrogen-rich water in enhancing wheat resilience and the dynamic subcellular interactions between mitochondria and chloroplasts in photosynthetic cells. The lab integrates computational modeling with experimental validation to advance sustainable agriculture and drug discovery.
Figures are computed from collected data and may differ slightly.
The phytochemicals of medicinal plants are regarded as a rich source of diverse chemical spaces that have been used as supplements and alternative medicines in the millennium. Even in this era of combinatorial chemical drugs, phytomedicines account for a large share of the statistics of newly approved drugs. In the field of computational aided and rational drug design, there is an urgent need to develop and build a useful phytochemical database management system with a user-friendly interface th
The subtype prevalence, drug resistance- and pathogenicity-associated mutations, and the distribution of the influenza A virus (IAV) isolates identified in Bangladesh from 2002 to 2019 were analyzed using bioinformatic tools. A total of 30 IAV subtypes have been identified in humans (4), avian species (29), and environment (5) in Bangladesh. The predominant subtypes in human and avian species are H1N1/H3N2 and H5N1/H9N2, respectively. However, the subtypes H5N1/H9N2 infecting humans and H3N2/H1N
The current coronavirus disease 2019 (COVID-19) pandemic, caused by the coronavirus 2 (SARS-CoV-2), involves severe acute respiratory syndrome and poses unprecedented challenges to global health. Structure-based drug design techniques have been developed targeting the main protease of the SARS-CoV-2, responsible for viral replication and transcription, to rapidly identify effective inhibitors and therapeutic targets. Herein, we constructed a phytochemical dataset of 1154 compounds using deep lit
Co-localization of mitochondria with chloroplasts in plant cells has long been noticed as beneficial interactions of the organelles to active photosynthesis. Recently, we have found that mitochondria in mesophyll cells of Arabidopsis thaliana expressing mitochondrion-targeted green fluorescent protein (GFP) change their distribution in a light-dependent manner. Mitochondria occupy the periclinal and anticlinal regions of palisade cells under weak and strong blue light, respectively. Redistribute
In the modern world, wheat, a vital global cereal and the second most consumed, is vulnerable to climate change impacts. These include erratic rainfall and extreme temperatures, endangering global food security. Research on hydrogen-rich water (HRW) has gained momentum in plant and agricultural sciences due to its diverse functions. This study examined the effects of different HRW treatment durations on wheat, revealing that the 4-h treatment had the highest germination rate, enhancing potential
Mitochondria are frequently observed in the vicinity of chloroplasts in photosynthesizing cells, and this association is considered necessary for their metabolic interactions. We previously reported that, in leaf palisade cells of Arabidopsis thaliana, mitochondria exhibit blue-light-dependent redistribution together with chloroplasts, which conduct accumulation and avoidance responses under the control of blue-light receptor phototropins. In this study, precise motility analyses by fluorescent
Aim: The aim of the study was to determine the influence of the size of permanent incisors on the appearance of the crowding of the anterior segment of dental arches.Materials and Methods: The study included 100 subjects, aged 13-25 years. All the examinees were divided into two groups. The first group comprised 50 subjects (25 males and 25 females) who had marked symptoms of crowding, especially in the anterior segment. The second group comprised 50 subjects (25 males and 25 females) with norma
Maxillary central incisor impactions occur infrequently.Their origins include various local causes, such as odontoma, supernumerary teeth, and space loss. Supernumerary and ectopically impacted teeth are asymptomatic and found during routine clinical or radiological examinations. The surgical exposure and orthodontic traction of impacted right central incisor after removal of odontomas is presented in this report.
 Ban J Orthod & Dentofac Orthop, April 2017; Vol-7 (1-2), P.31-37
This is a case report of a patient with a skeletal Class III malocclusion and maxillary arch deficiency. The patient was treated without extraction or surgery by increasing the maxillary arch length. Protraction of the maxillary complex and A point was the result. Favorable growth of both the maxilla and the mandible resulted in a functional Class I occlusion and an improved skeletal relationship.Ban J Orthod & Dentofac Orthop, October 2012; Vol-3, No.1
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