Kyung Hee University · Medicine
마이클 마에스 교수의 연구실은 우울증의 염증성 기전에 초점을 맞추고 있으며, 특히 면역 반응과 신경전달물질의 상호작용이 정서장애에 미치는 영향을 연구하고 있습니다. 주로 만성 염증 반응, 프로인flammatory 사이토카인, 장장벽 기능 이상과 관련된 내독소(LPS) 유입이 우울증, 특히 치료저항성 우울증(TRD)의 발병에 기여하는지를 탐구하고 있습니다. 또한 콜레스테롤 대사 이상과 항우울제의 면역조절 작용에 대한 기초 연구도 진행 중입니다.
Figures are computed from collected data and may differ slightly.
It is of considerable translational importance whether depression is a form or a consequence of sickness behavior. Sickness behavior is a behavioral complex induced by infections and immune trauma and mediated by pro-inflammatory cytokines. It is an adaptive response that enhances recovery by conserving energy to combat acute inflammation. There are considerable phenomenological similarities between sickness behavior and depression, for example, behavioral inhibition, anorexia and weight loss, a
There is now evidence that major depression (MDD) is accompanied by an activation of the inflammatory response system (IRS) and that pro-inflammatory cytokines and lipopolysacharide (LPS) may induce depressive symptoms. The aim of the present study was to examine whether an increased gastrointestinal permeability with an increased translocation of LPS from gram negative bacteria may play a role in the pathophysiology of MDD. Toward this end, the present study examines the serum concentrations of
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