The University of Osaka · Biochemistry, Genetics and Molecular Biology
Professor Michio Murata's research lab specializes in the isolation, structural elucidation, and total synthesis of complex marine natural products, particularly polyether toxins produced by dinoflagellates. His work focuses on understanding the intricate structures and absolute configurations of potent marine toxins such as ciguatoxins, maitotoxin, and okadaic acid derivatives, which are responsible for human illnesses like ciguatera and diarrhetic shellfish poisoning. The lab employs advanced spectroscopic techniques, including 2D NMR and carbon-hydrogen spin-coupling analysis, to determine stereochemistry and biosynthetic pathways of these bioactive compounds. Their research bridges marine chemistry, toxicology, and structural biology, contributing significantly to the understanding of marine ecosystem toxins and their origins.
Figures are computed from collected data and may differ slightly.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructures and configurations of ciguatoxin from the moray eel Gymnothorax javanicus and its likely precursor from the dinoflagellate Gambierdiscus toxicusMichio Murata, Anne M. Legrand, Yoshihiko Ishibashi, Masakazu Fukui, and Takeshi YasumotoCite this: J. Am. Chem. Soc. 1990, 112, 11, 4380–4386Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/ja00167a040https
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructures of ciguatoxin and its congenerMichio Murata, Anne M. Legrand, Yoshihiko Ishibashi, and Takeshi YasumotoCite this: J. Am. Chem. Soc. 1989, 111, 24, 8929–8931Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://pubs.acs.org/doi/10.1021/ja00206a032https://doi.org/10.1021/ja00206a032research-articleACS PublicationsRequest reuse permissionsArticle Views944Altmetric-Citatio
The major toxin involved in the diarrhetic shellfish poisoning was isolated from the hepatopancreas of the mussel Mytilus edulis and was named dinophysistoxin-1. It was obtained as a colorless solid: mp. 134°C, [d]20D 28°, LD99 160μg/kg (ip to mouse). Comparison of the toxin by various spectrometries with okadaic acid isolated from the marine dinoflagellate Prorocentrum lima established that dinophysistoxin-1 is 35S-methyl okadaic acid C45H70O13. Gas chromatographic analysis evidenced the presen
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of maitotoxinMichio Murata, Hideo Naoki, Takashi Iwashita, Shigeki Matsunaga, Masahiro Sasaki, Akihiro Yokoyama, and Takeshi YasumotoCite this: J. Am. Chem. Soc. 1993, 115, 5, 2060–2062Publication Date (Print):March 1, 1993Publication History Published online1 May 2002Published inissue 1 March 1993https://pubs.acs.org/doi/10.1021/ja00058a075https://doi.org/10.1021/ja00058a075research-articleACS PublicationsRequest reuse permissionsArticle Vie
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTAbsolute Configuration of Amphidinol 3, the First Complete Structure Determination from Amphidinol Homologues: Application of a New Configuration Analysis Based on Carbon−Hydrogen Spin-Coupling ConstantsMichio Murata, Shigeru Matsuoka, Nobuaki Matsumori, Gopal K. Paul, and Kazuo TachibanaView Author Information Department of Chemistry, School of Science The University of Tokyo, Hongo, Bunkyo-ku Tokyo 113-0033, Japan Cite this: J. Am. Chem. Soc. 1
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and Partial Stereochemical Assignments for Maitotoxin, the Most Toxic and Largest Natural Non-BiopolymerMichio Murata, Hideo Naoki, Shigeki Matsunaga, Masayuki Satake, and Takeshi YasumotoCite this: J. Am. Chem. Soc. 1994, 116, 16, 7098–7107Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/ja00095a013https://doi.org/10.1021/ja00095a013research-a
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPartial structures of maitotoxin, the most potent marine toxin from the dinoflagellate Gambierdiscus toxicusMichio Murata, Takashi Iwashita, Akihiro Yokoyama, Masahiro Sasaki, and Takeshi YasumotoCite this: J. Am. Chem. Soc. 1992, 114, 16, 6594–6596Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/ja00042a070https://doi.org/10.1021/ja00042a070research-article
The species-specific partnership between the sea anemone and anemone fish in many parts of the Indo-Pacific region is a well-known phenomenon. Chemicals secreted by the sea anemone to elicit symbiotic behavior of the fish have been studied for two host-guest pairs, Radianthus kuekenthali (sea anemone)-Amphiprion perideraion (anemone fish) and Stoichactis kenti-A. ocellaris. A new pyridinium compound, amphikuemin, which induces characteristic attracted swimming (toward the chemical stimulus) in A
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