Kyushu University · Medicine
Professor Mitsuru Tanaka's research lab specializes in metrology and analytical chemistry, with a focus on high-precision measurements of physical properties of water, including density and temperature relationships under standard conditions. The lab also conducts cutting-edge research in biomedical sciences, particularly in the transport mechanisms of bioactive peptides across biological barriers such as the blood-brain barrier and intestinal membranes. Their work bridges fundamental physical measurements with translational applications in neuroscience and peptide-based therapeutics.
Figures are computed from collected data and may differ slightly.
Experimental results from four recent research reports on the determination of the density/temperature relationship of Standard Mean Ocean Water (SMOW) under a pressure of 101 325 Pa are analysed and a new formula is recommended for metrological applications. This paper determines the formulae of density and relative density, with their uncertainties, in the temperature range 0 °C to 40 °C. The uncertainty estimation of one of the reports included in the analysis has been re-evaluated. Effects o
Heterodyne laser interferometry and its accuracy at subnanometer levels are discussed. The simplest optical nonpolarization heterodyne interferometer is tested experimentally to understand and reduce fringe distortion. An accuracy of 0.1 nm for the 633-nm He-Ne laser interferometer is achieved.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
Apart from nutrients required for the brain, there has been no report that naturally occurring peptides can cross the blood-brain barrier (BBB). The aim of this study was to identify the BBB-transportable peptides using in situ mouse perfusion experiments. Based on the structural features of Gly-N-methylated Gly (Gly-Sar), a reported BBB-transportable compound, 18 dipeptides were synthesized, and were perfused in the mouse brain for two minutes. Among the synthesized dipeptides, Gly-Sar, Gly-Pro
In this study, experiments on amyloid β peptide<sub>25-35</sub>-induced mice were performed to provide in vivo evidence on the potential of the blood-brain barrier transportable soy dipeptide, Tyr-Pro, in combating memory impairment. We demonstrated for the first time that oral administration of Tyr-Pro (100 mg/kg, twice a day) in mice for 16 days significantly improved impaired memory by spontaneous alternation and shortened step-through latency in amyloid β-induced mice.
To the best of our knowledge, this is the first study demonstrating that the vasoactive Trp-His is preferably transported across the rat intestinal membrane by PepT1 and is absorbed intact into the circulation. However, no absorption of His-Trp, a reverse sequence of absorbable Trp-His, is observed owing to hydrolysis by intestinal proteases. This suggests that the bioavailability of peptides may be determined in part by their protease resistance in the intestinal membrane.
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