Keio University · Medicine
Professor Mototsugu Oya's research lab focuses on the molecular mechanisms underlying cancer progression, particularly in colorectal and urothelial cancers, with an emphasis on the roles of inflammatory markers, transcription factors, and xenobiotic-sensing receptors. The lab investigates biomarkers such as D-dimer and CRP, as well as key signaling pathways like NF-κB and aryl hydrocarbon receptor (AhR), to understand their contributions to tumor stage, aggressiveness, and patient survival. Their work bridges clinical oncology and molecular pathology, aiming to improve preoperative diagnosis and postoperative prognosis prediction.
Figures are computed from collected data and may differ slightly.
Elevated plasma D-dimer levels in patients with colorectal cancer are associated with relatively advanced tumor stage and short postoperative survival after curative resection. It appears that measurement of preoperative D-dimer level would be useful in the preoperative diagnosis of tumor stage and prediction of postoperative survival.
Although an aggressive phenotype of renal cell carcinoma (RCC) is known to frequently be associated with inflammatory paraneoplastic syndrome including serum C-reactive protein (CRP) elevation, the molecular mechanism underlying this clinical phenomenon as well as what yields the malignant phenotype leading to the progression of RCC has yet to be elucidated. Based on the increased level of inflammatory cytokines such as interleukin-6 in advanced cases of RCC, a cytokine-inducible transcription f
Aryl hydrocarbon receptor (AhR) and the activation of the AhR pathway are involved in xenobiotic-induced toxicity and carcinogenesis. Although xenobiotics, such as cigarette smoke, contribute to the development of urothelial carcinoma (UC), the relationship between AhR and UC is unclear. In the present study, we investigated AhR expression in 209 patients with upper urinary tract UC. The nuclear expression of AhR was significantly associated with histological grade, pathological T stage, lymphov
Open papers in the app to read, cite, and organize with AI.
