Kyung Hee University · Medicine
Professor Nam-Jung Kim's research lab specializes in the development of innovative transition-metal-catalyzed methodologies for the efficient synthesis of bioactive heterocyclic compounds, with a strong focus on flavonoids and nitrogen-containing heterocycles such as benzodiazines and prostaglandins. The lab pioneers atom-economical, one-pot transformations using Pd(II) and Rh catalysts to enable concise, enantioselective access to complex natural products and pharmaceutical candidates. Additionally, the group explores surface-enhanced Raman spectroscopy using functionalized gold nanoparticle substrates to probe molecular dynamics and metal–molecule charge transfer at the nanoscale. Their work bridges synthetic organic chemistry, catalysis, and nanomaterials for applications in drug discovery and molecular sensing.
Figures are computed from collected data and may differ slightly.
In the recent decades, N-heterocycles are widely used as versatile scaffolds for the development of biologically active compounds and considered as one of the privileged structures. Among the various N-heterocycles, benzodiazines, a series of bicyclic heterocycles in which benzene rings are fused with 6-membered heterocycles containing two nitrogens are especially interesting, due to their structural conciseness and usefulness as synthetic intermediates, and suitable physicochemical properties a
A variety of flavones were expediently synthesized from readily accessible chromanones via a one-pot sequence involving Pd(II)-catalyzed dehydrogenation and oxidative boron-Heck coupling with arylboronic acid pinacol esters. In particular, the use of arylboronic acid pinacol esters was found to significantly improve the yield of the reaction.
Chemical enhancement of surface-enhanced Raman spectroscopy was investigated using a gold nanoparticle (AuNP)-coated polymer substrate, and an enormous b2-mode signal enhancement arose from the evaporation-induced reorientation of 4-aminobenzenethiol molecules adsorbed onto the AuNP surface. The dynamic analysis of time-dependent increases of chemically enhanced Raman signals enables us to measure the charge coupling strengths between molecules and metal at varying surface environments and to di
A total of 47 flavanones were expediently synthesized via one-pot β-arylation of chromanones, a class of simple ketones possessing chemically unactivated β sites, with arylboronic acids via tandem palladium(II) catalysis. This reaction provides a novel route to various flavanones, including natural products such as naringenin trimethyl ether, in yields up to 92%.
The concise and enantioselective synthesis of 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)) has been accomplished in 11 steps from a known alcohol. The key step of the synthesis involves an asymmetric Rh-catalyzed cycloisomerization of ene-ynone, followed by an olefin isomerization.
Divergent and versatile synthetic routes to flavones and flavanones <i>via</i> efficient Pd(ii) catalysis are disclosed. These Pd(ii) catalyses expediently provide a variety of flavones and flavanones from 2'-hydroxydihydrochalcones as common intermediates, depending on oxidants and additives, <i>via</i> discriminate oxidative cyclization sequences involving dehydrogenation, respectively, in a highly atom-economic manner.
An elusive chemical contribution to SERS is investigated by estimating the chemical coupling strengths through a dynamic relative peak analysis during solvent evaporation from a diluted chemical sample that is drop-deposited on a soft SERS substrate.
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