Hokkaido University · Medicine
Professor Naoki Hashimoto's research lab focuses on the intersection of organic chemistry and materials science, particularly in the development of fluorescent phosphine-based compounds with tunable photophysical properties. The lab also investigates chemical stability and degradation pathways in food systems, such as the formation of off-flavors in stored beer due to aldehyde generation via melanoidin-catalyzed oxidation. Additionally, the lab contributes to psychiatric pharmacology through clinical studies on antipsychotic treatment patterns and cognitive outcomes in schizophrenia, emphasizing medication optimization and long-term treatment effectiveness. These diverse research directions reflect a strong commitment to both fundamental chemical innovation and applied health sciences.
Figures are computed from collected data and may differ slightly.
Volatile aldehydes are formed during storage of bottled beer on the shelf and give the beer an off-flavour. Results showed that these aldehydes are formed by oxidation of higher alcohols in beer with melanoidins. On oxidation of the alcohols, hydrogen or an electron is probably transferred from the higher alcohols to reactive carbonyl groups of the melanoidins of lower molecular weights. The carbonyl groups are formed by the amino-carbonyl reaction during boiling of wort. Molecular oxygen does n
A practical synthesis of a variety of λ<sup>5</sup>-phosphinines, which show distinct fluorescence both in solution and solid state, is described. Both C4-selective electrophilic substitutions and the following conversions realized an easy preparation of a wide range of derivatives having several substituents for electronic modification, which provides the potential for fine-tuning of the photophysical properties.
A large sample size, uniform data collection methodology and robust statistical analysis are strengths of the current study. This result suggests that we need special attention to discuss about relationship between subcortical regional brain volumes and pathophysiology of schizophrenia because regional brain volumes may be affected by antipsychotic medication.
The current results suggest the positive effects of the training program in university settings in Japan. Future evaluation that includes comparison with standard didactic trainings and an assessment of long-term effectiveness are warranted.
In this open-label, single-arm study of 29 patients, quetiapine improved both the clinical symptoms and the neurocognitive impairment in chronic schizophrenia patients who failed to respond to prior antipsychotic treatment.
Our results showed the use of high doses of antipsychotics, high percentages of antipsychotic polypharmacy and concurrent use of hypnotics/anxiolytics in patients with schizophrenia. Notably, these data were collected before intensive instruction regarding the guidelines; therefore, we need to assess the change in the prescription pattern post guideline instruction.
Volatile aldehydes formed during storage of bottled beer on the shelf are generally considered to cause a stale flavor in beer. Oxidation of higher alcohols by melanoidins, oxidative degradation of isohumulones, Strecker degradation of amino acids, and autoxidation of unsaturated fatty acids are all involved in the formation of many kinds of volatile aldehydes. Evidence was presented in a previous paper that the aldehydes formed by oxidation of higher alcohols plus isohumulones may be the “stale
Isohumulones undergo oxidative degradation in bottled beer during shelf storage to give volatile compounds including 2-alkanones with chain lengths of C3 to C11, alkanals with chain lengths of C2 to C10 2-alkenals of C4 to C7 or more and 2,4-alkadienals of C6 to C7. Since some resultant aldehydes are involved in the formation of stale aldehydes, very high levels of isohumulones in beer may cause considerable staling of beer flavour. Isohumulones were decomposed to these carbonyl compounds more e
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