Nagoya University · Medicine
Professor Naoki Nishio's research lab specializes in image-guided surgical oncology, focusing on the development and clinical translation of molecular imaging agents for improved detection of lymph node metastases in head and neck cancers. The lab integrates near-infrared fluorescence imaging, photoacoustic molecular imaging, and targeted contrast agents—such as panitumumab-IRDye800CW—to enhance surgical precision and pathological evaluation. A key research direction involves optimizing en bloc resection techniques for advanced skull base tumors, including management of critical structures like the cavernous sinus, to improve oncological outcomes. The lab also explores regenerative medicine applications, particularly in using adipose-derived regenerative cells to improve outcomes in vocal fold paralysis.
Figures are computed from collected data and may differ slightly.
Identification of lymph node (LN) metastasis is essential for staging of solid tumors, and as a result, surgeons focus on harvesting significant numbers of LNs during ablative procedures for pathological evaluation. Isolating those LNs most likely to harbor metastatic disease can allow for a more rigorous evaluation of fewer LNs. Here we evaluate the impact of a systemically injected, near-infrared fluorescently-labeled, tumor-targeting contrast agent, panitumumab-IRDye800CW, to facilitate the i
The presence of lymph node (LN) metastases is an essential prognostic indicator in patients with head and neck squamous cell carcinoma (HNSCC). This study assessed photoacoustic molecular imaging (PAMI) of the antiepidermal growth factor receptor antibody (panitumumab) conjugated to a near-infrared fluorescent dye, IRDye800CW (panitumumab-IRDye800CW; pan800), for the identification of occult metastatic LNs in patients with HNSCC (<i>n</i> = 7). <b>Methods:</b> After in vitro photoacoustic imagin
This study only included cases of locally advanced maxillary sinus carcinoma classified as T4. Considering the advanced stage, our study suggests relatively favorable outcomes and the importance of managing the cavernous sinus in en bloc resections of malignant skull base tumors. Craniofacial resection in en bloc fashion achieved good survival rates.
The addition of a high concentration of adipose-derived regenerative cells to autologous fat injection therapy has the potential to improve the treatment outcome for unilateral vocal fold paralysis.
Preoperative 3D virtual surgical simulation and postoperative feedback can contribute to training for surgeons. © 2016 Wiley Periodicals, Inc. Head Neck 39: 512-519, 2017.
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Lingual node metastasis from early-stage squamous cell carcinoma of the tongue is uncommon and difficult to detect. We present a case of a lingual lymph node metastasis from an early tongue cancer. Sonography demonstrated a small nonpalpable lingual node on the floor of the mouth. The patient underwent complete surgical resection and had no evidence of recurrence 5 years later. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 46:69-72, 2018.
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