The University of Tokyo · Medicine
Professor Osamu Toyoshima's research lab specializes in endoscopic diagnosis and the long-term management of *Helicobacter pylori*-related gastritis, with a focus on the Kyoto classification system as a tool for assessing gastric atrophy, intestinal metaplasia, and gastric cancer risk. The lab investigates the impact of *H. pylori* eradication on endoscopic and serological markers, aiming to improve early detection and prognosis of gastric cancer. Key research directions include the longitudinal evaluation of endoscopic changes post-eradication and the use of serum antibody titers as non-invasive indicators of mucosal inflammation and cancer risk. The lab's work bridges clinical endoscopy, biomarker research, and preventive gastroenterology.
Figures are computed from collected data and may differ slightly.
Recent advances in endoscopic technology allow detailed observation of the gastric mucosa. Today, endoscopy is used in the diagnosis of gastritis to determine the presence/absence of <i>Helicobacter pylori (H. pylori)</i> infection and evaluate gastric cancer risk. In 2013, the Japan Gastroenterological Endoscopy Society advocated the Kyoto classification, a new grading system for endoscopic gastritis. The Kyoto classification organized endoscopic findings related to <i>H. pylori</i> infection.
Endoscopic gastric atrophy is a major risk factor for gastric cancer development after H. pylori eradication. Further long-term studies are required to determine whether H. pylori eradication leads to regression of H. pylori-related gastritis and reduces the risk of gastric cancer.
Endoscopic Kyoto classification of gastritis is a useful predictor of <i>H. pylori</i> infection in negative-high titer antibody patients.
Serum antibody titer changes with age, reflects gastric mucosal inflammation, and is useful in predicting the risk of gastric cancer.
Possible early discovery of gastric cancer after H. pylori eradication due to regular endoscopic surveillance may contribute to better prognosis of patients with gastric cancer.
The Kyoto classification score decreased following <i>H. pylori</i> eradication. A decrease in the scores for enlarged folds, nodularity, and diffuse redness contributed to the decrease in Kyoto score.
Among H. pylori-positive individuals, endoscopic and pathological diagnoses were consistent with atrophy and intestinal metaplasia. Enlarged folds, nodularity, and diffuse redness were associated with pathological inflammation (neutrophil activity and chronic inflammation) of the corpus; however, they were inversely associated with pathological atrophy and intestinal metaplasia. The endoscopy-based Kyoto classification of gastritis partially reflects pathology.
Endoscopic findings could predict false diagnoses determined using serum antibody titers.
This editorial provides an update of the recent evidence on the endoscopy-based Kyoto classification of gastritis, clarifying the shortcomings of the Kyoto classification, and providing prospects for future research, with particular focus on the histological subtypes of gastric cancer (GC) and <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection status. The total Kyoto score is designed to express GC risk on a score ranging from 0 to 8, based on the following five endoscopic findings: Atrophy
The Kyoto classification score was associated with the topographic distribution of neutrophil activity.
AIG progresses from the early phase to the end phase, and the APCA titer shows a decrease. The negativity of APCA could occur, especially in the end phase.
SNP rs2294008 in <i>Prostate Stem Cell Antigen</i> (<i>PSCA</i>) and decreased <i>PSCA</i> expression are associated with gastric cancer. The objective of this study is to investigate the role of rs2294008 and <i>PSCA</i> expression in the gastritis-gastric cancer carcinogenic pathway. We conducted a case-control association study of <i>H. pylori</i>-infected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (<i>P =</i> 9.4 × 10<sup>-5</sup>;
<b>Background and study aims</b> The benefits of the new-generation CF290 (Olympus, Tokyo, Japan) for pancolonic chromoendoscopy (PCC) for colorectal polyp detection and its procedure time remain questionable. We compared the CF290 with the previous CF260 for PCC. <b>Methods</b> We performed a propensity score-matching study using baseline characteristics such as age, sex, indications, endoscopist, and bowel preparation. We compared the detection of adenomas and sessile serrated polyps (SSPs) an
<b>Background and study aims </b> Adenoma detection rate (ADR) is an important quality indicator in colonoscopy, and improved ADR decreases the incidence of colorectal cancer. We investigated differences in polyp detection according to the endoscopist's ADR. <b>Patients and methods </b> We performed a propensity-score matching study using baseline patient characteristics of age, sex, body mass index, family history of colorectal cancer, smoking, drinking, indication for colonoscopy, bowel prepar
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