Tohoku University · Medicine
Professor Ryoukichi Ikeda's research lab specializes in otolaryngology, with a primary focus on the diagnosis, pathophysiology, and treatment of Eustachian tube (ET) disorders, particularly Eustachian Tube Dysfunction (ETD) and Paradoxical Eustachian Tube (PET) function. The lab investigates innovative interventions such as the Kobayashi Plug and balloon dilation tuboplasty (BET), emphasizing clinical outcomes, device efficacy, and the development of diagnostic criteria using imaging and functional testing. Their work also explores the surgical management of related conditions like cholesteatoma and labyrinthine fistulas, with a strong emphasis on preserving hearing and improving patient-reported outcomes.
Figures are computed from collected data and may differ slightly.
The management of habitual sniffing is difficult, but blocking the Eustachian tube by nasal instillation of saline and/or PEP could help PET patients to stop sniffing.
The success rate of the Kobayashi Plug for PET was 83.0% of a total (Prototype Plug 80.0%, New Plug 85.4%). In 26 ears, the Prototype Plugs were found to have descended toward the nasopharynx. Conversely, this did not happen with the New Plug. The rate of TM perforation (Prototype 22.6%, New 17.5%), middle ear effusion (Prototype 20.2%, New 10.2%) and ventilation tube placement (Prototype 14.8%, New 4.4%) decreased after transition to the New Plug.
Under resting conditions, the lengths of the closed area of the ETs in PET groups are clearly shorter than in groups without PET based on sitting position CT scans in resting condition. Among the symptoms and clinical test findings including the ET function test results, the presence of tympanic membrane movement induced by respiration, the high degree of EAC pressure change in TTAG, as well as the positive results of sonotubometry are significantly correlated with the positive findings of sitti
In smaller labyrinthine fistulas, complete removal of the cholesteatoma matrix can be relatively safely performed. However, in patients with larger fistulas, there is a potential for a complete loss of BC hearing.
The highest ETDQ-7 score was also observed in PET patients and in ET dysfunction patients. These findings necessitate careful discrimination between ET dysfunction and PET in balloon dilation Eustachian tuboplasty (BET) based on ETDQ-7.
The characteristics of main symptoms and the efficiency of various tests in PET diagnosis were analyzed based on data obtained from "Definite PET" patients diagnosed by the JOS Diagnostic Criteria. The greater the availability of tests to evaluate PET, the greater the opportunities to diagnose "Definite PET". In particular, tests measuring pressure transmission between the nasopharynx and middle ear, such as TM observation and TTAG, are more sensitive than sonotubometry measuring sound transmiss
2 Laryngoscope, 130:1304-1309, 2020.
Gentle suctioning and removal of the vestibular perilymph can cause a mild decrease in the EP even without damaging the inner ear structures. Therefore, suctioning of the perilymph should be avoided during stapes surgery because acute hearing loss can result even without damaging the inner ear structures. However, hearing loss may not be profound, if suctioning is not vigorous enough to cause damage to the inner ear structures.
Patients with patulous Eustachian tubes (PET) suffer from annoying aural symptoms, such as voice or breath autophony, and aural fullness due to the ET's abnormal patency. It may lead to an enormous reduction in quality of life. Various treatment methods, including conservative and surgical therapy, have been reported. In most cases, conservative treatment is sufficient to relieve patients of aural symptoms. However, some chronic and severe cases are resistant to traditional conservative therapy.
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We have described the diagnosis of PET based on the diagnostic criteria for PET proposed by JOS; PHI-10, Ohta method, and sitting CT are also useful for the diagnosis of PET. Further investigation is needed for an accurate diagnosis and precise evaluation of the pathophysiology of this challenging disease.
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