Kyoto University · Engineering
Professor Sadat Mohamed Rezk Khattab's research lab specializes in synthetic biology and metabolic engineering of yeast and microbial systems to develop sustainable bioprocesses for high-value nutraceuticals, biofuels, and biochemicals. The lab focuses on enhancing microbial cell factories through genetic optimization—particularly in glycerol and pentose sugar utilization—enabling efficient conversion of renewable feedstocks like lignocellulosic biomass and biodiesel-derived glycerol into bioethanol, 2,3-butanediol, and functional food ingredients. A key research direction involves engineering osmotolerant and robust yeast strains, such as *Meyerozyma guilliermondii* and *Saccharomyces cerevisiae*, to improve productivity under industrial conditions.
Figures are computed from collected data and may differ slightly.
The global nutraceutical industry is experiencing a paradigm shift, driven by an increasing demand for functional foods and dietary supplements that address malnutrition and chronic diseases such as obesity, diabetes, cardiovascular conditions, and cancer. Traditional plant- and animal-derived nutraceuticals face limitations in scalability, cost, and environmental impact, paving the way for microbial biotechnology as a sustainable alternative. Microbial cells act as bio-factories, converting nut
Glycerol is an eco-friendly solvent that enhances plant biomass decomposition via glycerolysis in many pretreatment methods. Nonetheless, inefficient conversion of glycerol to ethanol by natural Saccharomyces cerevisiae limits its use in these processes. In this study, we have developed an efficient glycerol-converting yeast strain by genetically modifying the oxidation of cytosolic NAD (NADH) by an O<sub>2</sub>-dependent dynamic shuttle and abolishing both glycerol phosphorylation and biosynth
The integration of AGL production with the co-fermentation of glycerol, hydrolyzed glucose, and xylose to produce a high titer of bioethanol paves an avenue for the use of surplus glycerol from the biodiesel industry for the efficient utilization of SCT and other lignocellulosic biomasses.
One osmotolerant strain from among 44 yeast isolates was selected based on its growth abilities in media containing high concentrations of sucrose. This selected strain, named SKENNY, was identified as Meyerozyma guilliermondii by sequencing the internal transcribed spacer regions and partial D1/D2 large-subunit domains of the 26S ribosomal RNA. SK-ENNY was utilized to produce high-fructose glucose syrup (HFGS) from sucrose-containing biomass. Conversion rates to HFGS from 310-610 g/l of pure su
2,3-Butanediol (2,3-BDO) has gained much attention due to its bulk chemical uses in numerous applications such as the production of pharmaceuticals, cosmetics, synthetic rubber, inks, resins, perfumes, foodstuffs, fuel additives, and aviation fuel.
Enhancing the robustness of microbial cell factories is essential for improving both first- and second-generation bioethanol production.
Besides the pledges for expanding uses of biofuels to sustain the humanosphere, abruptly massive needs emerged for sanitizers with turns COVID-19 to a pandemic. Therefore, ethanol is topping the social-demanding, although the three generations of production, from molasses/starch, lignocelluloses, and algae. Owing to the limited-availability of fermentable sugars from these resources, we addressed glycerol as a fourth bio-based carbon resource from biodiesel, soap, and fatty acid industries, whic
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