Yonsei University · Medicine
Professor Sang Ho Oh's research lab specializes in dermatological and cellular mechanisms underlying skin diseases, with a focus on stress responses, autophagy, and skin pigmentation disorders. The lab investigates molecular pathways involved in melanocyte biology, including melanosome regulation and melanogenesis, as well as the role of autophagy in skin homeostasis and disease. Additionally, the lab explores therapeutic applications of lasers and novel devices in treating scars, vitiligo, and acne, emphasizing translational approaches to improve clinical outcomes. Their work bridges basic cellular mechanisms with clinical dermatology, aiming to develop targeted, non-invasive treatments.
Figures are computed from collected data and may differ slightly.
Induction of metallothionein (a Zn-binding protein) was investigated in liver and kidneys of rats under the following stresses: cold environment, hot environment, heat burn, strenuous exercise, and CCl4 intoxication. As markers of metallothionein (MT) synthesis, [14C]cystine and 65Zn were injected parenterally into rats, and MT in liver and kidney supernatants was separated on Sephadex G-75 columns. Among stresses tested, the greatest stimulations of MT synthesis in liver were observed under col
Autophagy regulates cellular turnover by disassembling unnecessary or dysfunctional constituents. Recent studies demonstrated that autophagy and its regulators play a wide variety of roles in melanocyte biology. Activation of autophagy is known to induce melanogenesis and regulate melanosome biogenesis in melanocytes. Also, autophagy induction was reported to regulate physiologic skin color via melanosome degradation, although the downstream effectors are not yet clarified. To determine the role
We suggest that the FPS may provide a new treatment algorithm in some cases with acne scars and enlarged pores. Considering the lack of placebo-controlled, split-face design of our study, optimized, prospective studies should be conducted to fully assess the efficacy of FPS with dynamic operating mode.
Our results demonstrate that QS Nd:YAG laser with low fluence may be used for the treatment of keloids and hypertrophic scars.
External stimuli (e.g. oxidative stress and ultraviolet irradiation) may trigger HMGB1 release by keratinocytes, thereby perpetuating vitiligo through HMGB1-induced melanocytic apoptosis.
These findings may provide guidelines for the clinical differentiation between RAS and BD. In addition, patients with multiple major aphthae, particularly with articular symptoms, should be closely followed up for the development of BD, and the possibility of other diseases such as ankylosing spondylitis and Crohn's disease should also be considered.
Two major cytokines, IL-17A and IFN-α, may play roles in the pathogenesis of CLE. Their patterns of expression positively correlated with each other.
PDT with a long ALA incubation time might be more adequate for a pronounced outcome with inflammatory acne.
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