Seoul National University · Medicine
Professor Sang-Hwan Do's research lab focuses on the neuropharmacological mechanisms of anesthetic and analgesic agents, particularly exploring how drugs like magnesium sulfate, dexmedetomidine, lidocaine, and volatile anesthetics modulate neurotransmitter transporters such as EAAT3. The lab investigates the intracellular signaling pathways—especially protein kinase C and phosphatidylinositol 3-kinase—involved in these modulatory effects, aiming to enhance perioperative pain management and reduce opioid dependence. Using model systems like Xenopus oocytes, the lab elucidates the cellular and molecular basis of drug actions on excitatory amino acid transporters, with implications for improving anesthetic efficacy and neuroprotection.
Figures are computed from collected data and may differ slightly.
Magnesium sulfate has been used in preeclampsia patients in order to prevent seizure. It is also used for the treatment of arrhythmia and asthma and as an anesthetic adjunct in patients undergoing surgery for pheochromocytoma. However, its potentiating effects on perioperative analgesia and muscle relaxation have drawn attention recently. These characteristics of magnesium (anesthetic- and analgesic-sparing effect) enable anesthesiologists to reduce the use of anesthetics during surgery and the
Intraoperative dexmedetomidine sedation was associated with a small but clinically important reduction in postoperative opioid use after total knee arthroplasty.
These data suggest that volatile anesthetics enhance EAAT3 activity and that protein kinase C is involved in mediating these anesthetic effects.
By using the Xenopus oocyte expression system, we investigated the effects of lidocaine on a glutamate transporter (EAAT3). Our findings suggest that lidocaine enhances EAAT3 activity at certain concentrations and that protein kinase C and phosphatidylinositol 3-kinase may mediate these lidocaine effects.
In patients undergoing laparoscopic cholecystectomy, the combined use of ramosetron and dexamethasone was more effective than ramosetron alone for reducing the need for rescue antiemetics and pain control following the procedure.
Our results show that chronic ethanol exposure decreases EAAT3 activity at clinically relevant concentrations and that this effect may be protein kinase C-dependent. Such an effect could be a neuroadaptive mechanism to overcome the inhibitory effect of ethanol on the excitatory neurotransmission.
The combination of dexmedetomidine-remifentanil can reduce the incidence of respiratory depression without increasing hemodynamic complications compared with propofol-remifentanil for MAC during hysteroscopy.
By use of the Xenopus oocyte expression system, we investigated the effects of isoflurane on muscarinic signaling and the role of protein kinase C in these effects. Our findings suggest that isoflurane inhibits muscarinic receptors through activation of protein kinase C and that the relevant phosphorylation sites are located outside the third intracellular loop.
We aimed to investigate whether perioperative magnesium sulfate administration was associated with the incidence of chronic persistent postoperative pain (PPP) following total knee arthroplasty (TKA). This retrospective observational study was performed at a single tertiary academic hospital. We reviewed the medical records of adult patients who were admitted between August 2012 and July 2017. Patients who received magnesium sulfate during surgery were the magnesium group. The presence of PPP, o
Acute normovolemic haemodilution (ANH) may cause an imbalance in cerebral oxygen metabolism because it decreases the arterial oxygen content. This study was designed to investigate the effect of ANH on cerebral oxygenation. By using cerebral oximetry, the regional cerebral oxygen saturation (rSO2) was monitored during ANH in 26 patients without systemic illness (initial haematocrit = 42 +/- 1%). The rSO2 did not show a significant change until the Hct reached >30%. However, it decreased signific
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