Yonsei University · Medicine
Professor Sang Joon Shin's research lab specializes in translational oncology, focusing on the biological mechanisms and clinical management of rare and aggressive cancers, particularly mucosal melanoma. The lab investigates the synergistic effects of radiotherapy and immune checkpoint inhibitors to enhance anti-tumor responses and improve patient outcomes. Current research emphasizes optimizing combination therapies and understanding the tumor microenvironment's role in treatment resistance. The lab integrates clinical data with preclinical models to develop personalized treatment strategies for difficult-to-treat malignancies.
Figures are computed from collected data and may differ slightly.
<b>Objective:</b> Mucosal melanoma is an aggressive malignancy with a poor response to conventional therapies. The efficacy of radiotherapy (RT), especially combined with immune checkpoint inhibitors (ICIs), for this rare melanoma subtype remains unknown. We investigated the reciprocal effect of RT and ICI on mucosal melanoma patients. <b>Materials and Methods:</b> We identified 23 patients with 31 tumors who were treated with RT between July 2008 and February 2017. All patients received RT for
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