Korea University · Medicine
Professor Sang Wook Son's research lab focuses on the pathophysiology of inflammatory skin diseases, with a primary emphasis on psoriasis, atopic dermatitis, and rosacea. The lab investigates key molecular mechanisms involving cytokines (such as IL-33 and TSLP), transcription factors (like Egr-1 and HIF-1α), and signaling pathways (including BMP6 regulation) that drive abnormal keratinocyte proliferation and immune cell activation. Additionally, the lab explores the role of immune cell receptors, such as Fas and CD94/NKG2A on NK cells, in autoimmune skin disorders. The integration of clinical dermatology with molecular and cellular biology underpins the lab’s translational approach to identifying novel therapeutic targets.
Figures are computed from collected data and may differ slightly.
Together our results showed that anionic GNs penetrate skin better than cationic GNs.
A long-pulsed alexandrite laser without cryogen spray cooling is an effective and safe alternative in the treatment of BN.
Atopic dermatitis (AD) is a chronic inflammatory skin disease in which T-helper type 2 (Th2)-type immune responses are dominant. Th2 cytokine, interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP) have been suggested to have an important role in AD. IL-33 is highly expressed in AD, but its role in AD has not yet been fully understood. To further identify the role of IL-33 in AD, we investigated the expression of TSLP induced by IL-33 in keratinocytes. This study revealed that IL-33 induced
Hypoxia-inducible factor-1α (HIF-1α) has been reported to be up-regulated in psoriatic epidermis, resulting in increased proliferation and abnormal differentiation of human keratinocytes (KCs). However, the role of HIF-1α in psoriatic epidermis, which is mainly composed of KCs, is poorly understood. Here, we show that morphogenic protein 6 (BMP6) is down-regulated when HIF-1α is upregulated in patients with psoriasis skin lesions. HIF-1α overexpression in primary human KCs promoted proliferation
Journal Article The response of rosacea to eradication of Helicobacter pylori Get access S W Son, S W Son Departments of Dermatology, Search for other works by this author on: Oxford Academic Google Scholar I H Kim, I H Kim Departments of Dermatology, Search for other works by this author on: Oxford Academic Google Scholar C H Oh, C H Oh Departments of Dermatology, Search for other works by this author on: Oxford Academic Google Scholar J G Kim J G Kim Internal Medicine, Korea University College
Our findings demonstrate that changes in the expression of Fas and CD94/NKG2A receptors on NK cells may occur during new-onset psoriasis, and are likely to contribute to the pathogenesis of psoriasis.
The early growth response (Egr)-1 is a transcriptional factor which plays an important role in the regulation of cell growth, differentiation, cell survival and immune responses. Emerging evidences including our data demonstrate that the Egr-1 expression is up-regulated in the psoriatic skin lesions. The purpose of this study was to investigate the significance and regulatory mechanism of Egr-1 in the pathogenesis of psoriasis. Through microarray analysis, we found out that psoriasin (S100A7) ex
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