Ewha Womans University · Medicine
Professor Sang-Eun Lee's research lab specializes in cardiovascular imaging and myocardial microstructure analysis, with a focus on advanced cardiac MRI techniques such as diffusion tensor imaging (DTI) to understand structural heart disease at the microscopic level. The lab investigates the impact of therapies like statins on coronary atherosclerosis progression, emphasizing the differential effects on calcified versus non-calcified plaque. It also explores arrhythmia mechanisms in conditions like apical hypertrophic cardiomyopathy (ApHCM), highlighting the clinical significance of atrial fibrillation. The integration of ex-vivo DTI with innovative 3D histology and tissue-clearing methods enables high-resolution validation of myocardial fiber architecture in disease models.
Figures are computed from collected data and may differ slightly.
URL: https://www.clinicaltrials.gov. Unique identifier: NCT02803411.
In the non-statin group, CACS progression indicates the progression of both non-calcified and calcified PV progression. However, under the effect of statins, CACS progression indicates only calcified PV progression, but not non-calcified PV progression. Thus, the result of serial CACS should be differently interpreted according to the use of statins.
In patients with ApHCM, AF was common and was associated with a substantial risk for strokes and mortality suggesting that AF should be carefully managed in ApHCM.
We characterized the microstructural response of the myocardium to cardiovascular disease using diffusion tensor imaging (DTI) and performed histological validation by intact, un-sectioned, three-dimensional (3D) histology using a tissue-clearing technique. The approach was validated in normal (n = 7) and ischemic (n = 8) heart failure model mice. Whole heart fiber tracking using DTI in fixed ex-vivo mouse hearts was performed, and the hearts were processed with the tissue-clearing technique. Ca
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