Ewha Womans University · Medicine
Professor Sang-Jip Nam's research lab specializes in natural product chemistry, focusing on the isolation, structural elucidation, and biological evaluation of bioactive compounds from marine and terrestrial organisms. The lab primarily investigates meroterpenoids, polyketides, and terpenoids derived from marine bacteria and sponges, with an emphasis on their potential therapeutic applications in cancer, inflammation, and metabolic disorders. Advanced spectroscopic techniques, including 2D NMR, ECD, and HRMS, combined with the advanced Mosher's method, are routinely employed to determine complex structures and absolute configurations. The lab also explores structure-activity relationships to identify novel lead compounds for drug discovery.
Figures are computed from collected data and may differ slightly.
Fijiolide A, a potent inhibitor of TNF-alpha-induced NFkappaB activation, along with fijiolide B, were isolated from a marine-derived bacterium of the genus Nocardiopsis. The planar structures of fijiolides A (1) and B (2) were elucidated by interpretation of 2D NMR spectroscopic data, while the absolute configurations of these compounds were defined by interpretation of circular dichroism and 2D NMR data combined with application of the advanced Mosher's method. Fijiolides A and B are related t
<i>Salicornia europaea</i> L. is a halophyte that grows in salt marshes and muddy seashores, which is widely used both as traditional medicine and as an edible vegetable. This salt-tolerant plant is a source of diverse secondary metabolites with several therapeutic properties, including antioxidant, antidiabetic, cytotoxic, anti-inflammatory, and anti-obesity effects. Therefore, this review summarizes the chemical structure and biological activities of secondary metabolites isolated from <i>Sali
Meroterpenoids, meroindenon (<b>1</b>) and merochlorins E (<b>2</b>) and F (<b>3</b>), were isolated from a marine-derived bacterium belonging to the genus <i>Streptomyces</i>. Their chemical structures were established using extensive analysis of MS, UV, ECD, and NMR spectroscopic data. Compounds <b>1</b>-<b>3</b> possess a tetrahydroxynaphthalene core and a C<sub>15</sub>-isoprene unit. Compounds <b>2</b> and <b>3</b> exhibited strong antibacterial activities against <i>B. subtilis</i>, <i>K.
The isolation and structure elucidation of a new meroterpenoid, actinoranone (1), produced by a marine bacterium closely related to the genus Streptomyces is reported. Actinoranone is composed of an unprecedented dihydronaphthalenone polyketide linked to a bicyclic diterpenoid. The stereochemistry of 1 was defined by application of the advanced Mosher's method and by interpretation of spectroscopic data. Actinoranone (1) is significantly cytotoxic to HCT-116 human colon cancer cells with an LD50
Three new scalarane-based sesterterpenes, 1- 3, were isolated from a marine sponge of the genus Spongia, and their chemical structures were elucidated by analysis of HRMS and 2-D NMR spectra. The isolated compounds 1 and 3 showed inhibition against the farnesoid X-activated receptor (FXR) with IC50 values of 2.4 and 24 microM, respectively. In particular, compound 3 directly inhibited the interaction between FXR and a coactivator peptide (SRC-1) as determined by surface plasmon resonance (SPR) s
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