Yonsei University · Medicine
Professor Sang-Won Lee's research lab specializes in clinical and translational research focusing on medical imaging, inflammatory and autoimmune diseases, and spinal surgery techniques. The lab investigates diagnostic accuracy in liver steatosis using CT and histology, explores biomarkers such as lactate and systemic immune-inflammation index in critical illness and autoimmune conditions like lupus and vasculitis, and develops innovative spinal fixation methods to improve surgical outcomes. The work bridges radiology, rheumatology, critical care, and orthopedic surgery with an emphasis on early detection and personalized treatment strategies.
Figures are computed from collected data and may differ slightly.
Purpose: To retrospectively compare the accuracy of visual grading and the liver attenuation index in the computed tomographic (CT) diagnosis of 30% or higher macrovesicular steatosis in living hepatic donors, by using histologic analysis as the reference standard. Materials and Methods: Institutional review board approval was obtained with waiver of informed consent. Of 703 consecutive hepatic donor candidates, 24 patients (22 men and two women; mean age ± standard deviation, 36.3 years ± 9.7)
Lactic acidosis not hyperlactatemia was found to predict inhospital mortality more exactly in severe sepsis and septic shock patients. The acid-base state should be considered when attempting to predict the outcome of septic patients using serum lactate levels.
These data suggest that AD may play an anti-inflammatory role in the pathophysiology of RA.
The translaminar screw method avoided damaging vascular structures, especially when the vertebral artery courses in the C7 transverse foramen, and it maintains solid stabilization of the subaxial cervical spine. This technique has 2 important advantages to currently used techniques: it is simpler and is not limited by the position of vascular structures. Therefore, it may be applicable to a wider number of patients, especially as it may be used in the subaxial cervical spine.
Systemic immune-inflammation index at diagnosis could estimate the cross-section severe AAV and predict the poor outcomes in AAV patients.
Brain involvement in systemic lupus erythematosus (SLE) is a significant source of morbidity and mortality. Therefore, the early detection and treatment of brain involvement in SLE is of utmost importance; however, a confirmative diagnostic tool for neuropsychiatric SLE is yet to be developed. In this study, we investigated the efficacy of (18)F-FDG-PET for detection of brain involvement in patients with SLE with normal magnetic resonance imaging (MRI) findings. Twenty patients with SLE, who pre
The cumulative dose of leflunomide was the only independent predictor of abnormal LSM values in patients with RA who had received methotrexate for more than six months.
PIIV at diagnosis exceeding the optimal cut-off for death could predict all-cause mortality during follow-up in AAV patients comparable to male gender and FFS at diagnosis.
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