The University of Tokyo · Medicine
Professor Satoshi Sasaki's research lab focuses on nutritional epidemiology and dietary assessment, with a strong emphasis on the role of dietary patterns and specific nutrients in chronic disease prevention, particularly cardiovascular diseases and cancer. The lab develops and validates food frequency and diet history questionnaires (e.g., DHQ, BDHQ) to improve dietary intake estimation in population studies. Research also extends to the impact of diet on metabolic and endocrine health, including sleep quality, thyroid function, and hormonal regulation, with a particular interest in sodium, fatty acids, and micronutrient intake in free-living populations. The lab integrates dietary assessment with biomarker validation to strengthen the reliability of nutritional data in epidemiological research.
Figures are computed from collected data and may differ slightly.
In terms of food intake estimates, both the DHQ and the BDHQ showed reasonable validity.
A low intake of vegetables and fish, high intake of confectionary and noodles and unhealthy eating habits were independently associated with poor sleep quality. Poor sleep quality was also associated with high carbohydrate intake in free-living Japanese middle-aged female workers.
We developed a self-administered diet history questionnaire (DHQ) for use in prevention and control of cardiovascular diseases and cancer, and validated it by comparison with single 24-h urinary excretion of sodium (Na) and potassium (K). The subjects were 154 male and 69 female freshmen university students. Mean intakes (mmol/day) assessed by DHQ and the urinary excretion of Na were 196 and 165 respectively for men and 179 and 136 respectively for women. Those of K were 61.5 and 43.9 respective
We have previously disclosed the first potent and orally effective non-peptide antagonist for the human luteinizing hormone-releasing hormone (LHRH) receptor, a thieno[2,3-b]pyridin-4-one derivative, T-98475 (1). Extensive research on developing non-peptide LHRH antagonists has been carried out by employing a strategy of replacing the thienopyridin-4-one nucleus with other heterocyclic surrogates. We describe herein the design and synthesis of a series of thieno[2,3-d]pyrimidine-2,4-dione deriva
Although universal salt iodization has improved goiter rates, chronic exposure to excess iodine from water or poorly monitored salt are risk factors for hypothyroidism in free-living populations. Monitoring of both iodine concentration in salt as well as the iodine concentration in local drinking water are essential to preventing thyroid diseases. Hypothyroidism should be also carefully monitored in areas with excess iodine. Because of the low quality and limited number of included studies, furt
These results suggest that dietary factors, especially sodium and SFA, are of primary importance as determinants of stroke mortality at the population level.
While individual efforts to decrease Na intake remain important, population approaches to reducing Na content in processed foods are already equally important and will assume greater importance in the future even in Japan, an Asian country facing a rapid Westernization in dietary habits.
A cholera outbreak occurred in Lusaka city between November 28, 2003 and June 8, 2004, and 6,542 cases with 187 deaths (case fatality rata: 2.86) were reported. We analyzed the distribution of cholera cases, the mode of cholera transmission, and the risk factors affecting cholera infection in a peri-urban area of Lusaka by using a Geographic Information System (GIS) and a matched case-control method. Chloropleth mapping of the incidences of cholera showed variation of the incidences in the study
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