Sungkyunkwan University · Medicine
Professor Se Eun Park's research lab focuses on identifying novel biomarkers and pathophysiological mechanisms underlying type 2 diabetes mellitus and its complications. The lab investigates adipokines, myokines, hepatokines, and urinary biomarkers such as ACE2 and RBP4 to understand their roles in insulin resistance, metabolic dysregulation, and early diabetic kidney disease. A key research direction involves exploring autonomic nervous system dysfunction, particularly heart rate variability, as a predictive indicator of incident diabetes. The lab integrates clinical and translational research to support early diagnosis and personalized intervention strategies.
Figures are computed from collected data and may differ slightly.
Insulin resistance in insulin target tissues including liver, skeletal muscle and adipose tissue is an early step in the progression towards type 2 diabetes. Accurate diagnostic parameters reflective of insulin resistance are essential. Longstanding tests for fasting blood glucose and HbA1c are useful and although the hyperinsulinemic euglycemic clamp remains a "gold standard" for accurately determining insulin resistance, it cannot be implemented on a routine basis. The study of adipokines, and
Diabetes mellitus remains highly prevalent among Korean adults, with significant gaps in integrated glycemic, blood pressure, and lipid control. Older adults with diabetes show higher awareness and treatment rates but limited integrated management outcomes. Young adults with diabetes bear a significant burden of obesity and comorbidities, alongside low awareness and treatment rates. Therefore, early intervention programs, education, and strategies tailored to younger populations are urgently req
Our data suggest that the urinary ACE2 level is closely associated with T2DM and is an independent risk factor for microalbuminuria.
Urinary RBP4 concentrations were elevated in patients with dysregulation of glucose metabolism and were related to various cardiometabolic risk factors including insulin resistance, inflammation, and microalbuminuria.
Abnormal HRV, especially decreased vagal activity and deviation in sympathovagal imbalance to sympathetic activity, might precede incident diabetes.
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