Yonsei University · Engineering
Professor Seok Jun Moon's research lab focuses on the molecular and cellular mechanisms underlying sensory perception, particularly taste, mechanosensation, and hearing in *Drosophila melanogaster*. The lab investigates how sensory neurons detect and integrate chemical and mechanical stimuli through ion channels, G protein-coupled receptors, and signaling pathways such as PLC and TRP channels. A central theme is the role of membrane phosphoinositides and ciliary trafficking in sensory transduction, with key contributions to understanding the function of proteins like dINPP5E, dTULP, and GRs in sensory organ development and function. The lab also explores translational applications in neuroprosthetics and bio-inspired control systems, including semiactive vibration control in civil structures.
Figures are computed from collected data and may differ slightly.
Strychnine is a potent, naturally occurring neurotoxin that effectively protects plants from animal pests by deterring feeding behavior. In insects, such as the fruit fly, Drosophila melanogaster, bitter-tasting aversive compounds are detected primarily through a family of gustatory receptors (GRs), which are expressed in gustatory receptor neurons. We previously described multiple GRs that eliminate the behavioral avoidance to all bitter compounds tested, with the exception of strychnine. Here,
Animals use taste to sample and ingest essential nutrients for survival. Free fatty acids (FAs) are energy-rich nutrients that contribute to various cellular functions. Recent evidence suggests FAs are detected through the gustatory system to promote feeding. In Drosophila, phospholipase C (PLC) signaling in sweet-sensing cells is required for FA detection but other signaling molecules are unknown. Here, we show Gr64e is required for the behavioral and electrophysiological responses to FAs. GR64
The working group on bridge control within the ASCE Committee on Structural Control recently initiated a first-generation benchmark problem addressing the control of a cable-stayed bridge subjected to seismic excitation. Previous research examined the applicability of a LQG-based semiactive control system using magnetorheological (MR) dampers to reduce the structural response of the benchmark bridge and confirmed the capability of the MR damper-based system for seismic response reduction. In thi
The integration of two or more distinct sensory cues can help animals make more informed decisions about potential food sources, but little is known about how feeding-related multimodal sensory integration happens at the cellular and molecular levels. Here, we show that multimodal sensory integration contributes to a stereotyped feeding behavior in the model organism <i>Drosophila melanogaster</i> Simultaneous olfactory and mechanosensory inputs significantly influence a taste-evoked feeding beh
Gene drive systems that propagate transgenes via super-Mendelian inheritance can potentially control insect-borne diseases and agricultural pests. However, concerns have been raised regarding unforeseen ecological consequences, and methods that prevent undesirable gene drive effects have been proposed. Here, we report a chemical-induced control of gene drive. We prepared a CRISPR-based gene drive system that can be removed by a site-specific recombinase, Rippase, the expression of which is induc
Glycolysis is responsible for the conversion of glucose into pyruvate and for supplying reducing power and several metabolites. Fructose-1,6-bisphosphate aldolase (AtFBA1), a central enzyme in the glycolysis pathway, was isolated by functional complementation of the salt-sensitive phenotype of a calcineurin (CaN)-deficient yeast mutant. Under high salinity conditions, aldolase activity and the concentration of NADH were compromised. However, expression of AtFBA1 maintained aldolase activity and
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