Seoul National University · Medicine
Professor Seong-Doo Hong's research lab specializes in cancer pharmacology and molecular oncology, focusing on the anticancer mechanisms of natural compounds, particularly norcantharidin (NCTD), in various human malignancies. The lab investigates the apoptotic, anti-invasive, and anti-metastatic effects of NCTD in oral squamous cell carcinoma and mucoepidermoid carcinoma, with an emphasis on identifying key molecular targets and signaling pathways. Their work integrates in vitro and in vivo models to elucidate the therapeutic potential of NCTD and related compounds in cancer treatment.
Figures are computed from collected data and may differ slightly.
In order to verify its validity as a prognostic factor, this study investigated the relationship between Akt gene expression and its upstream regulator and downstream target genes, as well as the association between activated Akt expression and clinicopathological factors, E‐cadherin, mdm2, PCNA, and VEGF. 4 fresh tissues and 3 cell lines were examined using oligonucleotide microarray. Surgical specimens from 84 patients with OSCC were examined for phosphorylated Akt(P‐Akt), E‐cadherin, mdm2, PC
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