Yonsei University · Medicine
Professor Seung-Jun Lee's research lab focuses on vascular biology and gastrointestinal physiology, with a particular emphasis on the roles of key signaling molecules such as angiopoietin-2 and glucagon-like peptide-2 receptor in cardiovascular and intestinal homeostasis. The lab investigates mechanisms underlying vascular remodeling, inflammation, and tissue repair in ischemic heart disease and gut injury, aiming to identify novel therapeutic targets for age-related and inflammatory vascular disorders. Recent work also explores non-invasive drug delivery strategies using ultrasound technology. The lab integrates preclinical models with molecular and cellular analyses to translate findings into clinical applications.
Figures are computed from collected data and may differ slightly.
Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular destabilizing factor, is a biomarker of poor outcome in ischemic heart disease. However, its precise role in postischemic cardiovascular remodeling is poorly understood. Here, we show that Angpt2 plays multifaceted roles in the exacerbation of cardiac hypoxia and inflammation after myocardial ischemia. Angpt2 was highly expressed in endothelial cells at the infarct border zone after myocardial infarction (MI) or
Exogenous glucagon-like peptide-2 receptor (GLP-2R) activation elicits proliferative and cytoprotective responses in the gastrointestinal mucosa and ameliorates experimental small and large bowel gut injury. Nevertheless, the essential physiological role(s) of the endogenous GLP-2R remain poorly understood. We studied the importance of the GLP-2R for gut growth, epithelial cell lineage allocation, the response to mucosal injury, and host-bacterial interactions in Glp2r(-/-) and littermate contro
These results indicate the feasibility of using a low-cost, lightweight cymbal array for enhanced transdermal insulin delivery using ultrasound.
Arterial ageing is characterized by age associated degeneration and sclerosis of the media layer of the large arteries. However, besides ageing, clinical conditions, which enhance oxidative stress and inflammation act to accelerate the degree of arterial ageing. In this review, we summarized the pathophysiology and contributing factors that accelerate arterial ageing. Among them, we focused on hypertension, the renin-angiotensin-aldosterone system and vascular inflammation which are modifiable c
Venule-dependent arteriolar vasoconstriction in NOD mice is mediated by thromboxane and/or angiotensin II.
Abstract This study reports on highly efficient nonlinear optical ionic quinolinium crystals with various aromatic anions possessing different spatial volume for controlling the space‐filling characteristics and introducing halogen substituents having simultaneous electron‐withdrawing and electron‐donating effects. The quinolinium crystals with chloro and bromo substituents having simultaneous electron‐withdrawing and electron‐donating effects on anions exhibit perfect molecular ordering for opt
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