Kyoto University · Medicine
Professor Shigeru Tsunoda's research lab specializes in translational oncology with a focus on esophageal squamous cell carcinoma (ESCC). The lab investigates molecular mechanisms underlying tumor progression, including the roles of ABCG2-positive cells and nerve growth factor (NGF) signaling in cancer aggressiveness and metastasis. Their work integrates clinical pathology with molecular biology to identify novel prognostic biomarkers and therapeutic targets. The lab also evaluates surgical outcomes and postoperative imaging in gastrointestinal malignancies, emphasizing early detection and intervention.
Figures are computed from collected data and may differ slightly.
The absolute presence of ABCG2-positive cells in the tumor is a single independent prognostic factor, suggesting the underlying roles in malignant characteristics of ESCC other than drug resistance.
TLTG is feasible and can be performed with acceptable postoperative morbidity. A longer operating time and more advanced pathologic stage were significantly associated with higher postoperative morbidity.
Nerve growth factor (NGF) is overexpressed not only in nervous system, but also in several types of cancers. However, the role of NGF in oesophageal squamous cell carcinoma (OESCC) remains unclear. Here, we show the first evidence of NGF-TrkA autocrine loop and clinical significance of NGF overexpression in OESCC. Immunohistochemical study of 109 OESCC specimens revealed that NGF overexpression, found in 63 out of 109 patients (57.8%), was associated with lymph node metastasis, distant metastasi
Approximately 1 in 125 patients who underwent laparoscopic surgery for reflux or a large hiatus hernia had an important finding on an early postoperative contrast swallow, and benefited from this investigation by undergoing early reoperative intervention.
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