Keio University · Medicine
Shinichiro Nakajima 교수의 연구실은 주로 정신질환의 뇌과학적 기반을 밝히는 데 초점을 맞추고 있습니다. 주로 우울증과 조현병에서의 시냅스 기능 이상과 뇌의 흥분성·억제성 균형 이상을 전자마취요법(TMS)과 뇌전도(EEG)를 융합한 비침습적 뇌기능 측정 기법을 통해 연구하고 있습니다. 특히, 뇌의 신경가소성과 뇌 예비력(brain reserve)의 역할에 대한 기전적 이해를 목표로 하며, 정신질환의 신경생물학적 기전을 규명하는 데 기여하고 있습니다.
Figures are computed from collected data and may differ slightly.
Major depressive disorder (MDD) is a mental illness with high socio-economic burden, but its pathophysiology has not been fully elucidated. Recently, the cortical excitatory and inhibitory imbalance hypothesis and neuroplasticity hypothesis have been proposed for MDD. Although several studies have examined the neurophysiological profiles in MDD using transcranial magnetic stimulation (TMS), a meta-analysis of TMS neurophysiology has not been performed. The objective of this study was to compare
Our findings suggest that education may exert a protective effect on total brain volume in the MCI stage but not in HC or AD. Thus, education may play an important role in preventing the onset of dementia through brain reserve in MCI.
Schizophrenia (SCZ) is a serious mental disorder, and its pathogenesis is complex. Recently, the glutamate hypothesis and the excitatory/inhibitory (E/I) imbalance hypothesis have been proposed as new pathological hypotheses for SCZ. Combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG) is a non-invasive novel method that enables us to investigate the cortical activity in humans, and this modality is a suitable approach to evaluate these hypotheses. In this study, we
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