Nagoya University · Medicine
Professor Shiro Imagama's research lab focuses on spinal cord injury, neurodegenerative diseases, and surgical outcomes in spinal surgery. The lab investigates the molecular mechanisms underlying amyotrophic lateral sclerosis (ALS), particularly the role of glycosaminoglycans like keratan sulfate in disease progression, as well as factors influencing postoperative complications and hospital length of stay after spinal interventions. The team integrates clinical neurosurgery with molecular biology to improve surgical planning, patient outcomes, and informed consent through evidence-based risk factor analysis and intraoperative neuromonitoring strategies.
Figures are computed from collected data and may differ slightly.
The factors identified in this study should help with obtaining informed consent, surgical planning and complication prevention to reduce health care costs associated with prolonged LOS.
Biopolymers consist of three major classes, i.e., polynucleotides (DNA, RNA), polypeptides (proteins) and polysaccharides (sugar chains). It is widely accepted that polynucleotides and polypeptides play fundamental roles in the pathogenesis of neurodegenerative diseases. But, sugar chains have been poorly studied in this process, and their biological/clinical significance remains largely unexplored. Amyotrophic lateral sclerosis (ALS) is a motoneuron-degenerative disease, the pathogenesis of whi
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Age, preoperative VAs, and corrected VAs are risk factors for EO-AVFs after kyphoplasty.
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In spinal cord monitoring with intraoperative Br(E)-MsEP, an alarm point using a decrease in amplitude of ≥ 70% and delay in onset latency of ≥ 10% from baseline has high specificity that reduces false positive results.
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