The University of Osaka · Immunology and Microbiology
Shizuo Akira 교수의 연구실은 숙주 면역 반응의 핵심 기전인 TLR(톨 수용체)를 통한 내재면역 반응의 시그널링 경로를 중심으로 연구를 진행하고 있습니다. 특히 MyD88과 TRIF와 같은 시그널링 분자들이 면역 반응 조절에 어떻게 기여하는지에 대한 기초 메커니즘을 규명해 왔으며, 이는 감염병과 만성 염증 질환의 이해에 기여하고 있습니다. 또한, IL-6, TNF 등 다기능성 사이토카인의 기능과 병리적 역할에 대해서도 전임상 모델을 통해 심층적으로 연구하고 있습니다.
Figures are computed from collected data and may differ slightly.
Stimulation of Toll-like receptors (TLRs) triggers activation of a common MyD88-dependent signaling pathway as well as a MyD88-independent pathway that is unique to TLR3 and TLR4 signaling pathways leading to interferon (IFN)-beta production. Here we disrupted the gene encoding a Toll/IL-1 receptor (TIR) domain-containing adaptor, TRIF. TRIF-deficient mice were defective in both TLR3- and TLR4-mediated expression of IFN-beta and activation of IRF-3. Furthermore, inflammatory cytokine production
The innate immune response in vertebrates is the first line of defense against invading microorganisms. The main players in innate immunity are phagocytes such as neutrophils, macrophages, and dendritic cells. These cells can discriminate between pathogens and self by utilizing signals from the Toll-like receptors (TLRs) 1The abbreviations used are: TLR, Toll-like receptor; IL, interleukin; IL-1R, interleukin-1 receptor; TIR, Toll/IL-1R; LRR, leucine-rich repeat; IRAK, IL-1RI-associated protein
Interleukin 1 (IL 1), IL 6, and tumor necrosis factor (TNF) are typical examples of multifunctional cytokines involved in the regulation of the immune response, hematopoiesis, and inflammation. Their functions are widely overlapping but each shows its own characteristic properties. IL 6 was originally identified as a B cell differentiation factor, and thus one of the major functions of IL 6 is antibody induction. Transgenic mice have provided much needed information on the pathophysiological rol
Open papers in the app to read, cite, and organize with AI.
