Nagoya University · Medicine
Professor Sho Tano's research lab specializes in maternal and perinatal health, with a focus on interpregnancy care and the prevention of obstetric complications. The lab investigates the impact of weight management—particularly annual BMI changes—on the risk of hypertensive disorders of pregnancy (HDP), gestational diabetes mellitus (GDM), and preterm birth (PTB). Using large-scale retrospective cohort data from multiple medical facilities, the lab develops predictive models and identifies actionable clinical targets, such as optimal BMI gain trajectories, to reduce adverse pregnancy outcomes. Their work bridges clinical practice and public health by translating epidemiological findings into practical counseling strategies.
Figures are computed from collected data and may differ slightly.
The present study found that vaginal GBS colonization in the early stage of pregnancy was associated with PTB. Our study indicates that patients at a high risk for PTB can be extracted by a simple method using conventional culture method.
Weight gain during interpregnancy period is related to hypertensive disorders of pregnancy (HDP). However, in interpregnancy care/counseling, the unpredictability of the timing of the next conception and the difficulties in preventing age-related body weight gain must be considered while setting weight management goals. Therefore, we suggest considering the annual change in the body mass index (BMI). This study aimed to clarify the association between annual BMI changes during the interpregnancy
For women with a pre-pregnant BMI of <25.0 kg/m<sup>2</sup> and without GDM during the index pregnancy, maintaining an annual BMI gain of <0.6 kg/m<sup>2</sup>/year may prevent GDM during the subsequent pregnancy.
Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality. Although PTB is known to recur, interpregnancy preventive strategies for PTB have not been established to date. Annual BMI change can serve as a specific target value for preventing obstetric complications during interpregnancy care/counseling. This value can also account for age-related weight gain (0.2 kg/m<sup>2</sup>/year). In a multicenter retrospective study, we investigated the optimal annual BMI change for preven
A pattern of marked initial-increase and minor subsequent-decrease (i.e., sustained hyperglycemia) was associated with EoHDP. Contrarily, the pattern of marked initial-increase and subsequent-decrease (i.e., increased GV) was associated with LoHDP. This provides a new perspective for future study strategies.
The growing recognition of the importance of interpregnancy weight management in reducing hypertensive disorders of pregnancy (HDP) underscores the importance of effective preventive strategies. However, developing effective systems remains a challenge. We aimed to bridge this gap by constructing a prediction model. This study retrospectively analyzed the data of 1746 women who underwent two childbirths across 14 medical facilities, including both tertiary and primary facilities. Data from 2009
Non-immune hydrops fetalis (NIHF) indicates the risk for stillbirth. Although the causes vary and most NIHFs have no identifiable cause, recent advances in exome sequencing have increased diagnostic rates. We report a case of NIHF that developed into a giant cystic hygroma complicated by maternal mirror syndrome. Trio-based exome sequencing showed a de novo heterozygous missense variant in the <i>RIT1</i> (NM_006912: c.246 T > G [p.F82L]). The <i>RIT1</i> variants are known causative variants of
This is the first report showing that age-related weight gain was reduced after the COVID-19 pandemic in Japan, which could affect the reproductive age of females.
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