Nagoya University · Medicine
Professor Shunsuke Onoe's research lab specializes in gastrointestinal and hepatobiliary oncology, with a focus on the pathological classification, prognostic stratification, and surgical management of rare and complex gastrointestinal cancers, including pancreaticobiliary and duodenal carcinomas. The lab investigates clinicopathological features, survival outcomes, and biomarkers such as the lymphocyte-to-monocyte ratio (LMR) to improve risk assessment and treatment decisions. Their work emphasizes the biological and clinical continuity among subtypes of pancreaticobiliary cancer, advocating for integrated, individualized approaches to resectable disease.
Figures are computed from collected data and may differ slightly.
PCC survival decreased with progression of the invasive component. PCC with >50% invasive component was clinicopathologically similar to NPCC. Although IPNB might be nosologically applied only for PCC cases with ≤50% invasive component, the present prognostic delineation suggests that all PCC subgroups belonged to a singular disease group.
LMR may carry important prognostic information for patients with resectable PHC. Preoperative LMR may be considered for use in risk stratification for individual patients with PHC.
原発性十二指腸癌は比較的まれであり, 切除しえた自験例10例について臨床病理学的検討を行った. 対象患者の平均年齢は72.7歳, 男性8人, 女性2人であった. 主訴は嘔吐が5人で最も多く, 全例有症状で発見され, 診断時進行癌であった. 占居部位は球部から下行脚が多く, 大部分に膵頭十二指腸切除が行われた. 肉眼型は2型が5例, 組織型は中分化型腺癌が5例と多くみられた. リンパ節転移陽性率は70%であった. 5年生存率は58%であり, 他の膵頭部領域癌と比較して長期生存が望めると考えられた. 最近10年間の国内の論文73例を集計し, 壁深達度, リンパ節転移, 膵浸潤の有無が予後規定因子と考えられた. リンパ節転移陽性例, 膵浸潤例でも長期生存がみられたことから, 現時点では積極的な拡大手術が長期生存に寄与すると考える.
As Paget's disease is frequently accompanied by underlying intraductal and/or invasive carcinoma, patients should be carefully selected for breast conserving surgery.
PCC-M and PCC-NM were similar in morphology and prognosis. Although a few clinicopathological differences exist between them, their overlapping features and identical survival curves appear to justify the lack of a specific treatment modality for either type.
Although autologous blood transfusion may minimize postoperative hyperbilirubinemia, it may not decrease the risk for mortality or morbidities following hepatectomy for BTC.
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