Yonsei University · Medicine
Professor So Mi Jemma Cho's research lab focuses on cardiovascular disease prevention, with a strong emphasis on dyslipidemia, polygenic risk scores, and individualized risk prediction. The lab investigates how genetic, clinical, sociodemographic, and lifestyle factors interact to influence coronary artery disease (CAD) risk and recurrence, particularly in diverse populations. Using large-scale clinical data and health system-based studies, the lab aims to improve risk stratification and precision prevention strategies. Their work spans from basic genetic associations to real-world implementation of risk models in clinical settings.
Figures are computed from collected data and may differ slightly.
Dyslipidemia continues to impose a substantial disease burden in Korea. Both healthcare practitioners and patients need to actively adopt guideline-recommended lifestyle modification and pharmacological treatment for comprehensive, timely, and sustained management.
Sociodemographic, clinical, and laboratory factors are each associated with CAD recurrence with genetic risk, age at first CAD event, and HDL cholesterol concentration explaining the most.
ClinicalTrials.gov NCT03300271; http://clinicaltrials.gov/ct2/show/NCT03300271.
Separate examination of individual dyslipidemia parameter indicated varying degree of interaction with age and education level. Such results imply that each type of lipid abnormality may arise from and be exacerbated by heterogeneous composition of biological and lifestyle risk factors, which may be reflected by education level.
Blood pressure polygenic risk score may augment identification of individuals at heightened cardiovascular risk, including those with both normal blood pressure and hypertension. Whether it may also guide antihypertensive initiation or intensification requires further study.
The PREVENT model moderately discriminated ASCVD incidence across 4 geographically distinct academic health care systems in the United States. However, calibration metrics varied widely across health care systems, sociodemographics, and underlying cardiometabolic comorbidities.
Changes in each subtype prevalence made differential contribution to additionally classified hypertension cases by the 2017 ACC/AHA guideline. Future studies should investigate the diastolic-associated cardiovascular risks and benefits of its long-term primary prevention in the young population.
Snoring is associated with impaired glucose metabolism even in otherwise metabolically healthy adults. Habitual snorers may require lifestyle modifications and pharmacological treatment to improve glycemic profile.
Our findings confer that maintaining favourable health behaviours and clinical risk factor levels in midlife will improve later-life cardiovascular outcomes.
Among individuals with normal systolic BP, cumulative DBP may augment cardiovascular disease risk stratification beyond a single DBP measure and traditional risk factors.
Separate examination of control rates demonstrated different sex- and age-differential trends, which would have been overlooked in combined control rates.
The proportion of Korean adults with ideal cardiovascular health decreased between 2007 and 2018, but the course of responsible factors differed across sex and age groups.
Monitoring diurnal and nocturnal BP may identify chronic kidney disease otherwise overlooked based on OBP.
Physical activity has been known to deter inflammatory process; yet, the evidence is scarce in healthy, middle-aged population. We assessed the association between physical activity and inflammatory biomarkers, including high sensitivity (hs) C-reactive protein, interleukin (IL)-1α, -1β, and -6, tumor necrosis factor (TNF) -α and -β, and monocyte chemotactic protein (MCP) -1 and -3. Functional and leisure-time physical activity was assessed by the International Physical Activity Questionnaire. I
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