Yonsei University · Medicine
Professor Sung-Hwan Kim's research lab focuses on regenerative medicine and orthopedic tissue engineering, with a primary emphasis on articular cartilage repair and osteoarthritis (OA) pathogenesis. The lab investigates the molecular mechanisms underlying cartilage degeneration, particularly the regulatory roles of microRNAs such as miR-449a in mesenchymal stem cell differentiation and chondrogenesis. Additionally, the lab explores surgical techniques for anterior and posterior cruciate ligament reconstruction, with a special interest in remnant preservation and its impact on joint stability and functional outcomes. Their work bridges molecular biology and clinical orthopedics to develop novel therapeutic strategies for joint diseases.
Figures are computed from collected data and may differ slightly.
Traumatic and degenerative lesions of articular cartilage usually progress to osteoarthritis (OA), a leading cause of disability in humans. MicroRNAs (miRNAs) can regulate the differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) and play important roles in the expression of genes related to OA. However, their functional roles in OA remain poorly understood. Here, we have examined miR-449a, which targets sirtuin 1 (SIRT1) and lymphoid enhancer-binding factor-1 (LEF-1), and
Techniques combining remnant-preserving transtibial single-bundle PCL reconstruction with posterolateral corner reconstruction resulted in somewhat better activity-related outcomes compared with those of approaches without remnant preservation. However, incorporation of remnant preservation does not appear to provide increased posterior stability or result in clinically superior outcomes versus those of techniques without remnant preservation.
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