Hanyang University · Biochemistry, Genetics and Molecular Biology
Professor Sungyong Mun's research lab specializes in advanced separation science, with a primary focus on simulated moving bed (SMB) technology for the purification of biochemicals, particularly insulin and other biopharmaceuticals. The lab develops innovative SMB configurations—such as tandem and multi-zone systems—using rate-model simulations and optimization tools to enhance separation efficiency, yield, and purity while minimizing costs. Key research directions include residence time distribution analysis, robust operation under parameter variations, and systematic optimization of both system and operating parameters. The lab's work bridges fundamental separation principles with industrial applications in pharmaceutical and biochemical processing.
Figures are computed from collected data and may differ slightly.
A tandem simulated moving bed (SMB) was developed previously for the purification of insulin from two impurities in two sequential steps. In this study, an efficient optimization tool based on the standing wave design is developed to find the optimal tandem SMB for insulin purification. Both system parameters (total number of columns, zone configuration, column diameter, and column length for each ring) and operating parameters (zone flow rates and switching time for each ring) are optimized to
A tandem simulated moving bed (SMB) has been developed previously to purify insulin from two impurities in two sequential steps. In this study, rate-model simulations are used to investigate how variations in operating and system parameters affect the yield and purity of the SMB. The parameters include the pump outputs, step time, bed voidage, size-exclusion factor, and extra-column dead volume. The results show that a robust pump configuration can minimize the effects of pump output deviations.
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