Hanyang University · Engineering
Professor Sungyoung Choi's research lab specializes in microfluidic technologies for label-free, non-invasive cell and particle manipulation, with a focus on hydrodynamic and dielectrophoretic principles. The lab develops innovative microdevices that exploit hydrophoretic forces—generated by structured microchannels and obstacles—to achieve high-throughput, sheathless focusing, separation, and sizing of microparticles, blood cells, and platelets with minimal shear stress. A key research direction involves leveraging intrinsic physical differences such as size and dielectric properties for cell cycle synchronization and rare cell sorting, enabling applications in clinical diagnostics and regenerative medicine. The lab emphasizes simplicity, scalability, and physiological compatibility in its microfluidic platform designs.
Figures are computed from collected data and may differ slightly.
This communication presents a microfluidic method for size-based cell sorting, which provides a simple and robust approach for cell cycle synchronization by manual and stand-alone operation.
Three-dimensional (3D) measurement of the behavior of microfluidic particles is vital for improving their operational efficiency and characterization. In particular, it is important to measure particle motions in 3D for exact characterization of hydrophoresis, which utilizes 3D convective flows for size separation. Herein, the 3D measurement of hydrophoretic particle ordering for the exact characterization of hydrophoresis by using an optically coated mirror-embedded microchannel is reported. Th
A smart multi-pipette for hand-held operation of microfluidic devices is presented and applied to cytotoxicity assays and micro-droplet generation. This method enables a continuous-flow and accurate pumping simply by pushing the plunger of the smart multi-pipette, thereby obviating the need for auxiliary equipment and special expertise in microfluidics. We applied the smart multi-pipette to a cytotoxicity assay using a gradient-generating device and water droplet generation using a T-junction de
Miniaturizing flow cytometry requires a comprehensive approach to redesigning the conventional fluidic and optical systems to have a small footprint and simple usage and to enable rapid cell analysis. Microfluidic methods have addressed some challenges in limiting the realization of microflow cytometry, but most microfluidics-based flow cytometry techniques still rely on bulky equipment (e.g., high-precision syringe pumps and bench-top microscopes). Here, we describe a comprehensive approach tha
Simple and low-cost implementation of three-dimensional (3D) particle measurement is vital for designing and characterizing microfluidic devices that show spatiotemporally varying characteristics in three dimensions. However, the conventional 3D particle image velocimetry or particle streak velocimetry has proven difficult to address the needs, requiring complex and expensive equipment, precise alignment between optical components, and specialized image-processing algorithms. Here, we report mir
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