Kyoto University · Medicine
Professor Susumu Satô's research lab specializes in photophysical processes in rare earth complexes, with a focus on intramolecular energy transfer mechanisms in europium and terbium chelates. The lab investigates the role of triplet states, resonance energy transfer, and thermal deactivation pathways in enhancing fluorescence efficiency. Their work combines time-resolved spectroscopy with theoretical modeling to optimize luminescent materials for biomedical and analytical applications. Additionally, the lab explores the structure-activity relationships of therapeutic agents, such as antiepileptic drugs, in neurological disorders.
Figures are computed from collected data and may differ slightly.
Abstract The fluorescence yield of europium chelates in several solutions varies, through its maximum value, with the increase in the energy difference between the triplet state of a ligand and the emitting level of an europium ion. The time-resolved spectroscopic measurements show that the excitation energy is transferred from the triplet state to the lower and nearest resonance level of the europium ion. The intramolecular energy transfer mechanisms for europium chelates and terbium chelates a
Valproic acid (VPA) and ethosuximide (ESM) were compared in a double-blind, response- conditional crossover study of absence seizures in 16 naive (previously untreated for absence seizures) and 29 refractory patients (18 male and 27 female; 4 to 18 years of age). In the naive patients VPA was as effective as ESM in reducing generalized spike-wave discharges on the telemetered EEG. Adverse reactions to VPA or ESM were generally mild and responded to withdrawal or dosage reduction of the drug.
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