The University of Osaka · Medicine
Professor Tadahiro Sasaki's research lab specializes in infectious disease diagnostics and virology, with a focus on antimicrobial resistance, emerging viral pathogens, and the development of rapid, accurate diagnostic tools. The lab investigates the molecular epidemiology of antibiotic-resistant bacteria such as CTX-M-producing Enterobacteriaceae and explores host-pathogen interactions in viral infections, including SARS-CoV-2 and dengue virus. A key research direction involves the development of novel therapeutic and diagnostic platforms, such as engineered ACE2 decoys and quantitative viral load assays, to combat evolving viral variants and improve clinical management. The lab also contributes to point-of-care testing innovation to enhance diagnostic accuracy and reduce inappropriate antimicrobial use.
Figures are computed from collected data and may differ slightly.
The study revealed the wide dissemination of CTX-M beta-lactamase-producing Enterobacteriaceae in the healthy population.
The Omicron variant continuously evolves under the humoral immune pressure exerted by vaccination and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and the resulting Omicron subvariants display further immune evasion and antibody escape. An engineered angiotensin-converting enzyme 2 (ACE2) decoy composed of high-affinity ACE2 and an IgG1 Fc domain could offer an alternative modality to neutralize SARS-CoV-2. We previously reported its broad spectrum and therapeutic pote
Since the coronavirus disease 2019 (COVID-19) outbreak, laboratory diagnosis has mainly been conducted using reverse-transcription polymerase chain reaction (RT-PCR). Detecting the presence of an infectious virus in the collected sample is essential to analyze if a person can transmit infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, there have been no quantitative investigations conducted for infectious SARS-CoV-2 in clinical samples. Therefore, in the present st
Concomitant use of SEA-IC and PDM-IC kits increased the likelihood of correct influenza diagnosis. Increasing the credibility of POCT is anticipated to decrease the inappropriate dispensing of anti-influenza drugs, thereby minimizing the emergence of drug-resistant H1N1pdm strains.
Dengue is a mosquito-borne disease that has spread to over 100 countries. Its symptoms vary from the relatively mild acute febrile illness called dengue fever to the much more severe dengue shock syndrome. Dengue is caused by dengue virus (DENV), which belongs to the Flavivirus genus of the family Flaviviridae. There are four serotypes of DENV, i.e., DENV1 to DENV4, and each serotype is divided into distinct genotypes. Thailand is an endemic area where all four serotypes of DENV co-circulate. Ge
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