Hanyang University · Medicine
Professor Tae-Hwan Kim's research lab focuses on the intersection of immunology, microbiology, and herbal medicine, with a particular emphasis on the pathogenesis of inflammatory diseases such as ankylosing spondylitis and reactive arthritis, where HLA-B27 and microbial interactions play a central role. The lab also investigates the therapeutic potential of traditional herbal medicines, especially Korean and mountain ginseng, in treating conditions like erectile dysfunction, using rigorous clinical and physiological approaches. Research spans from molecular mechanisms of immune response to translational studies in human health. The lab integrates molecular tracing techniques, such as 15N labeling, to study plant stress responses, particularly in nitrogen metabolism and osmoprotectant accumulation under drought stress.
Figures are computed from collected data and may differ slightly.
In ankylosing spondylitis and reactive arthritis, an interplay of microbe and major histocompatibility complex initiates a sequence of events resulting in chronic inflammation. With the use of molecular probes as direct evidence and immune response patterns as indirect evidence, a strong case has been made for a central role of local microbial antigen in reactive arthritis. Cofactors such as gender, persistent gut inflammation, and antibiotic treatment may contribute to this process. Studies of
Korean ginseng and mountain ginseng (Panax ginseng CA Meyer) are important traditional herbal plants whose ginsenosides are generally accepted as serving to improve sexual functions, such as penile erection. We investigated the effects of tissue-cultured mountain ginseng extract (TMGE) on male patients with erectile dysfunction (ED). A double-blind, placebo-controlled study was conducted with 143 patients experiencing ED. Over the course of 8 weeks, one group took 1 000 mg of TMGE twice a day, a
The kinetics of protein incorporation from newly-absorbed nitrogen (N, de novo protein synthesis) was estimated by <sup>15</sup>N tracing in 18-week-old white clover plants (Trifolium repens L. cv. Regal) during 7 d of water-deficit treatment. The physiological relationship between kinetics and accumulation of proline and ammonia in response to the change in leaf-water parameters was also assessed. All leaf-water parameters measured decreased gradually under water deficit. Leaf and root dry mass
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