Kyoto University · Biochemistry, Genetics and Molecular Biology
Professor Taiji Adachi's research lab specializes in computational biomechanics and bone tissue engineering, focusing on the multi-scale mechanisms of bone remodeling and adaptation. The lab develops advanced computational models—such as voxel and boxel finite element methods—to simulate trabecular bone surface remodeling in response to mechanical stimuli, integrating cellular mechanosensing (e.g., osteocyte fluid flow shear stress) with tissue-level adaptation. Their work bridges molecular-scale mechanotransduction with macroscopic bone structure and disease, enabling in silico exploration of metabolic bone disorders like osteoporosis and osteopetrosis. The lab also extends its modeling framework to soft rock mechanics, demonstrating a broader interest in elasto-plastic constitutive behavior in porous materials.
Figures are computed from collected data and may differ slightly.
A computational simulation method for three-dimensional trabecular surface remodeling was proposed, using voxel finite element models of cancellous bone, and was applied to the experimental data. In the simulation, the trabecular microstructure was modeled based on digital images, and its morphological changes due to surface movement at the trabecular level were directly expressed by removing/adding the voxel elements from/to the trabecular surface. A remodeling simulation at the single trabecul
In this study, to investigate mechanical remodeling of cancellous bone from the viewpoint of trabecular surface remodeling due to trabecular level mechanical stimuli, a rate equation for trabecular surface remodeling is proposed based on the uniform stress hypothesis, which suggests that nonuniformity in the local stress distribution on the trabecular surface is the driving force for remodeling. A proposed local rate equation for trabecular surface remodeling is applied to a computational simula
In bone functional adaptation by remodelling, osteocytes in the lacuno-canalicular system are believed to play important roles in the mechanosensory system. Under dynamic loading, bone matrix deformation generates an interstitial fluid flow in the lacuno-canalicular system; this flow induces shear stress on the osteocytic process membrane that is known to stimulate the osteocytes. In this sense, the osteocytes behave as mechanosensors and deliver mechanical information to neighbouring cells thro
Abstract Dense sands, overconsolidated clays and soft rocks exhibit strain‐hardening and strain‐softening behaviour in a certain range of confining pressure. The aim of the present paper is to construct a constitutive model of soft rock that can describe not only the strain‐hardening behaviour, but also the strain‐softening behaviour. An elasto‐plastic constitutive model for soft rock is derived by introducing a stress history tensor The preliminary idea was first reported in the reference, the
Bone structure and function are maintained by well-regulated bone metabolism and remodeling. Although the underlying molecular and cellular mechanisms are now being understood, physiological and pathological states of bone are still difficult to predict due to the complexity of intercellular signaling. We have now developed a novel in silico experimental platform, V-Bone, to integratively explore bone remodeling by linking complex microscopic molecular/cellular interactions to macroscopic tissue
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