Kyoto University · Materials Science
Professor Takashi Nozawa's research spans cardiovascular physiology and microbial pathogenesis, with a focus on the biomechanics of cardiac function and the molecular mechanisms of bacterial immune evasion. His lab investigates ventricular efficiency and energy transfer in the heart using hemodynamic and volumetric measurements in animal models, while also exploring how pathogens like Group A Streptococcus manipulate host autophagy pathways through small GTPases such as Rab9A and Rab23. A key theme across his work is the interplay between host cellular machinery and microbial virulence factors, particularly in the context of horizontal gene transfer and immune modulation.
Figures are computed from collected data and may differ slightly.
We studied the effects of ventricular end-systolic elastance (Ees) and effective arterial elastance (Ea) on the efficiency of energy transfer from pressure-volume area (PVA) to external mechanical work (EW) in the left ventricle of anesthetized closed-chest dogs. PVA represents the total mechanical energy generated by ventricular contraction, which is an intermediate form of energy between oxygen consumption, the total energy input, and EW, the effective energy output. PVA and EW were determined
Streptococcus pyogenes, one of the major human pathogens, is a unique species since it has acquired diverse strain-specific virulence properties mainly through the acquisition of streptococcal prophages. In addition, S. pyogenes possesses clustered regularly interspaced short palindromic repeats (CRISPR)/Cas systems that can restrict horizontal gene transfer (HGT) including phage insertion. Therefore, it was of interest to examine the relationship between CRISPR and acquisition of prophages in S
The relationship between the total loss under tensile stress and the tilt angle of the [001] out of crystal surface β was studied in 3 percent Si-Fe single crystals. The total loss largely depends upon β. When β is about 2°, the total loss under tensile stress is the smallest, and the decrease of the total loss due to tensile stress is the largest. When β is less than about 2°, the total loss increases as β decreases. In the case of perfect
Autophagy mediates the degradation of cytoplasmic contents in the lysosome and plays a significant role in immunity. Here we identified the small GTPases Rab9A and Rab23 as novel autophagy regulators during Group A streptococcus (GAS) infection. Rab9A was recruited to GAS-containing autophagosome-like vacuoles (GcAVs) after autophagosomal maturation and its activity was required for GcAV enlargement and eventual lysosomal fusion. GcAV enlargement appeared to be related to homotypic fusion of GcA
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