The University of Osaka · Chemistry
Professor Takato Mitsudome's research lab specializes in the design and development of advanced heterogeneous nanocatalysts for sustainable organic transformations. The lab focuses on creating core–shell and supported nanoparticle systems—particularly using hydrotalcite, ceria, and noble metals like Ag, Au, Pd, and Cu—for selective and efficient catalytic reactions such as dehydrogenation, oxidation, and hydrogenation under mild, additive-free, or oxidant-free conditions. A key research direction involves engineering interfacial sites between metal cores and oxide shells to enhance selectivity and activity, enabling high turnover numbers and reusability. The lab’s work emphasizes green chemistry principles, aiming to replace stoichiometric oxidants and harsh reaction conditions with reusable, earth-abundant, or base-metal-based catalysts.
Figures are computed from collected data and may differ slightly.
Additive free: Hydrotalcite-supported silver nanoparticles act as a highly efficient heterogeneous catalyst for the dehydrogenation of diverse alcohols (see picture) in the absence of any acceptors such as molecular oxygen, hydrogen peroxide, or unsaturated organic compounds. The solid Ag catalyst was readily reusable without any loss of activity and selectivity. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z703161_s.pdf or f
Shelling out: A core–shell nanocomposite comprising an Ag nanoparticle core and a CeO2 nanoparticle shell catalyzes the chemoselective reduction of both nitrostyrenes and epoxides while retaining the CC bonds (see picture). Reactions with the core–shell structures show greater chemoselectivity than conventional oxide-supported metal nanoparticles.
Just the one: The combination of palladium dichloride and N,N-dimethylacetamide (DMA) constitutes a highly efficient and reusable catalytic system, which uses molecular oxygen as the sole reoxidant for liquid-phase Wacker oxidation and acetoxylation of terminal olefins to the corresponding methyl ketones and linear allylic acetates, respectively (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z502886_s.pdf or from
We report a facile synthesis of new core-Au/shell-CeO2 nanoparticles (Au@CeO2) using a redox-coprecipitation method, where the Au nanoparticles and the nanoporous shell of CeO2 are simultaneously formed in one step. The Au@CeO2 catalyst enables the highly selective semihydrogenation of various alkynes at ambient temperature under additive-free conditions. The core-shell structure plays a crucial role in providing the excellent selectivity for alkenes through the selective dissociation of H2 in a
Abstract Hydrotalcite‐supported gold nanoparticles (Au/HT) were found to be a highly efficient heterogeneous catalyst for the aerobic oxidation of alcohols under mild reaction conditions (40 °C, in air). This catalyst system does not require any additives and is applicable to a wide range of alcohols, including less reactive cyclohexanol derivatives. This Au/HT catalyst could also function in the oxidation of 1‐phenylethanol under neat conditions; the turnover number (TON) and turnover frequency
We have developed a highly efficient heterogeneous catalytic system using hydrotalcite-supported Cu nanoparticles (Cu/HT) that can successfully promote the oxidant-free dehydrogenation of various alcohols under liquid-phase conditions.
Bon Apatite! Hydroxyapatite-supported silver nanoparticles act as a highly efficient heterogeneous catalyst for the oxidation of diverse phenylsilanes into silanols in water (see picture; C orange, H red, O blue, R purple, Si green), while suppressing significant condensation to the disiloxanes. The solid silver catalyst is readily reusable without any loss of activity or selectivity. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2
Hydroxyapatite-supported silver nanoparticles (AgHAP) acted as a highly efficient reusable heterogeneous catalyst for hydration of diverse nitriles, including heteroaromatic ones, into amides in water.
We designed core-Pd/shell-Ag nanocomposite catalyst (Pd@Ag) for highly selective semihydrogenation of alkynes. The construction of the core–shell nanocomposite enables a significant improvement in the low activity of Ag NPs for the selective semihydrogenation of alkynes because hydrogen is supplied from the core-Pd NPs to the shell-Ag NPs in a synergistic manner. Simultaneously, coating the core-Pd NPs with shell-Ag NPs results in efficient suppression of overhydrogenation of alkenes by the Pd N
Hydroxyapatite-supported gold nanoparticles (AuHAP) can act as highly efficient and reusable catalysts for the oxidation of diverse silanes into silanols in water; this is the first catalytic methodology for the selective synthesis of aliphatic silanols using water under organic-solvent-free conditions.
Catalysts with a sheltered upbringing: Novel core–shell nanocomposite catalysts consisting of active metal nanoparticles encapsulated by macroligands have been prepared. They have Pd nanoparticles (PdNPs) as an active core and shell ligands having sulfoxide moieties coordinated to the PdNPs. The shell protects the catalyst from coordination by alkenes and allows the lead-free selective semihydrogenation of a wide range of alkynes without any additives (see scheme).
Taking the ′O′: Supported gold and silver nanoparticles (NPs), which are well-known epoxidation catalysts, were found to have intrinsic catalytic ability for the deoxygenation of epoxides into alkenes using alcohol as a reductant (see picture). The selectivity for all the alkenes were over 99 %, and an excellent turnover number was achieved. Furthermore, these supported gold and silver nanoparticles were recyclable. Detailed facts of importance to specialist readers are published as ”Supporting
The oxidative lactonization of various diols using molecular oxygen as a primary oxidant can be efficiently catalyzed by hydrotalcite-supported Au nanoparticles (Au/HT). For instance, lactonization of 1,4-butanediol gave γ-butyrolactone with an excellent turnover number of 1400. After lactonization, the Au/HT can be recovered by simple filtration and reused without any loss of its activity and selectivity.
A simple catalyst system consisting of PdCl2 and N,N-dimethylacetamide (DMA) as the solvent can successfully promote Wacker-type oxidation of internal olefins. This catalyst system does not require copper compounds and is tolerant of a wide range of substrates having internal olefins. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. P
Ohne Zusätze: Silbernanopartikel auf Hydrotalcit-Trägern wirken hoch effizient in der heterogenkatalysierten Dehydrierung von Alkoholen (siehe Bild), wobei auf Akzeptoren wie molekularen Sauerstoff, Wasserstoffperoxid oder ungesättigte organische Verbindungen verzichtet werden kann. Der Katalysator kann ohne Aktivitäts- und Selektivitätsverlust wiederverwendet werden. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2008/z703161_s.pdf
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