The University of Osaka · Medicine
Professor Takaya Kitano's research lab specializes in cerebrovascular diseases, with a primary focus on ischemic stroke, mechanical thrombectomy, and the pathophysiology of stroke complications such as hemorrhagic transformation and brain edema. The lab investigates biomarkers—particularly serum and autoantibody markers—associated with stroke outcomes and paraneoplastic syndromes, and explores the impact of thrombus maturity and reperfusion quality (e.g., mTICI scores) on clinical recovery. The team also examines the neurological manifestations of underlying malignancies, such as thymoma, and their immune-mediated mechanisms.
Figures are computed from collected data and may differ slightly.
In our study, the elevated stroke risk in cancer patients who received chemotherapy was presumably due to advanced cancer stage; chemotherapy was not associated with the increased risk of stroke.
An older thrombus delays reperfusion after mechanical thrombectomy for ischemic stroke. Adding therapies targeting thrombus maturation may improve the efficacy of mechanical thrombectomy.
As the goal of mechanical thrombectomy is shifting toward mTICI-3 rather than mTICI-2b, we sought to clarify the limitation of the effect of mTICI-3. A post-hoc analysis of a registry of large-vessel occlusion stroke from 46 centers was conducted. Among 2,420 registered patients, 725 patients with anterior circulation occlusion who achieved successful reperfusion were analyzed. We compared outcomes between patients with mTICI-3 and mTICI-2b, and investigated how the effect of mTICI-3 changed acc
Among patients with acute ischemic stroke, increased AEC was independently associated with the presence of CAPs. Our results suggest that AEC may be a useful predictor for the presence of CAPs in these patients.
Serum biomarkers are associated with hemorrhagic transformation and brain edema after cerebral infarction. However, whether serum biomarkers predict hemorrhagic transformation in large vessel occlusion stroke even after mechanical thrombectomy, which has become widely used, remains uncertain. In this prospective study, we enrolled patients with large vessel occlusion stroke in the anterior circulation. We analyzed 91 patients with serum samples obtained on admission. The levels of matrix metallo
A 87-year-old female presented with subacute progression of cognitive decline. Fluid-attenuated inversion recovery images of brain MRI showed multifocal high-intensity lesions. Thoracic CT image revealed the presence of thymoma, and serum autoantibody screening showed positivity for anti-gamma aminobutyric acid (GABA)<sub>A</sub> receptor antibody. Histopathological analysis confirmed type B3 thymoma after thymectomy. The patient received both plasmapheresis and intravenous methylprednisolone th
Objective The underlying pathophysiology varies according to stroke subtype. However, stroke heterogeneity among patients with systemic lupus erythematosus (SLE) remains unstudied. We hypothesized that the contribution of SLE to stroke might vary according to its subtype and investigated the associations of SLE and various stroke subtypes. Methods Diagnostic codes and electronic medical records were used to identify 70 patients with SLE who developed acute cerebral infarction or intracerebral he
Objective: A case of iatrogenic dural arteriovenous fistula that occurred during embolization of a feeding artery for transverse sinus (TS) dural arteriovenous fistula is reported.
Libman-Sacks endocarditis is a prevalent complication in patients with systemic lupus erythematosus or antiphospholipid syndrome (APS).[1][1] Although antithrombotic therapy can prevent thromboembolic events in APS, the optimal anticoagulation regimen remains uncertain. Here, we present a case of
Collectively, our findings indicate that <i>SPP1</i>-high monocytes/macrophages play a crucial role in thrombus maturation.
Delayed stenosis of targeted vessels is a reported complication of stent retriever-based mechanical thrombectomy.1 We report a case of delayed stenosis with MRI findings that may be related to the underlying stenotic mechanism. A 46-year-old woman was brought to our hospital with sudden left hemiparesis and unilateral spatial neglect. MRI revealed occlusion of the right middle cerebral artery (MCA) and acute cerebral infarction (figure 1A,B). Emergent mechanical thrombectomy was performed with
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