Tokyo Institute of Technology · Biochemistry, Genetics and Molecular Biology
Professor Takehiko Itoh's research lab specializes in comparative genomics and evolutionary genetics, focusing on understanding the genetic basis of human uniqueness through comparative analyses of primate genomes. The lab investigates the evolutionary origins and genomic architecture of polyploid and hybrid species, such as the lager beer yeast *Saccharomyces pastorianus*, using next-generation sequencing and bioinformatic approaches. Their work bridges evolutionary biology and genomics, aiming to unravel the mechanisms of genome divergence, hybridization, and adaptation. The lab also contributes to the development of high-resolution comparative genome maps to identify lineage-specific genomic changes.
Figures are computed from collected data and may differ slightly.
The recently released human genome sequences provide us with reference data to conduct comparative genomic research on primates, which will be important to understand what genetic information makes us human. Here we present a first-generation human-chimpanzee comparative genome map and its initial analysis. The map was constructed through paired alignment of 77,461 chimpanzee bacterial artificial chromosome end sequences with publicly available human genome sequences. We detected candidate posit
The lager beer yeast Saccharomyces pastorianus is considered an allopolyploid hybrid species between S. cerevisiae and S. eubayanus. Many S. pastorianus strains have been isolated and classified into two groups according to geographical origin, but this classification remains controversial. Hybridization analyses and partial PCR-based sequence data have indicated a separate origin of these two groups, whereas a recent intertranslocation analysis suggested a single origin. To clarify the evolutio
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