Takeo Miyake

Enzymatic biofuel cells have attracted much attention for their potential to directly use biochemical energy sources in living organisms such as animals, fruits, etc. However, generally natural organisms have a skin, and the oxygen concentration in the organisms is lower than that of biofuels like sugars. Here, we fabricated a novel miniature assembly that consists of a needle bioanode for accessing biofuels in organisms through their skins and a gas-diffusion biocathode for utilizing the abunda

Nanostructured carbons have been widely used for fabricating enzyme-modified electrodes due to their large specific surface area. However, because they are random aggregates of particular or tubular nanocarbons, the postmodification of enzymes to their intrananospace is generally hard to control. Here, we describe a free-standing film of carbon nanotube forest (CNTF) that can form a hybrid ensemble with enzymes through liquid-induced shrinkage. This provides in situ regulation of its intrananosp

In 1804, Theodore von Grotthuss proposed a mechanism for proton (H(+)) transport between water molecules that involves the exchange of a covalent bond between H and O with a hydrogen bond. This mechanism also supports the transport of OH(-) as a proton hole and is essential in explaining proton transport in intramembrane proton channels. Inspired by the Grotthuss mechanism and its similarity to electron and hole transport in semiconductors, we have developed semiconductor type devices that are a

Real-time imaging of single-molecule fluorescence with a zero-mode waveguide (ZMW) was achieved. With modification of the ZMW geometry, the signal-to-background ratio is twice that obtainable with a conventional ZMW. The improved signal-to-background ratio makes it possible to visualize individual binding-release events between chaperonin GroEL and cochaperonin GroES at a concentration of 5 microM. Two rate constants representing two-timer kinetics in the release of GroES from GroEL were measure

Abstract Contact lens with built‐in electronics is a next‐generation wearable product with potential applications such as biomedical sensing and wearable displays. However, fabricating a wireless‐powered circuit on a moist, soft contact lens, via common dry lithography, makes producing smart contact lenses challenging. Here, electrochemically (EC) printing a wireless‐powered circuit onto a moist, soft contact lens is demonstrated. EC printing involves adding a conductive polymer at the interface

Abstract Powering an electrical contact lens is a significant challenge for wearable applications such as augmented reality displays and iontophoretic drug delivery to the eye. Here a hybrid power generation device is developed comprising a wireless power transfer system and a bioabsorbable metal–air primary battery, which provides a multifunctional direct current (DC) and/or alternating current (AC) output. The DC power is generated by Zn loop anode and a bilirubin oxidase (BOD) biocathode in a

Translating ionic currents into measureable electronic signals is essential for the integration of bioelectronic devices with biological systems. We demonstrate the use of a Pd/PdHx electrode as a bioprotonic transducer that connects H+ currents in solution into an electronic signal. This transducer exploits the reversible formation of PdHx in solution according to PdH↔Pd + H+ + e−, and the dependence of this formation on solution pH and applied potential. We integrate the protonic transducer wi