Kyushu University · Biochemistry, Genetics and Molecular Biology
Professor Takeru Nose's research spans polymer physics and biophysical chemistry, with a focus on the thermodynamic and dynamic behavior of polymer solutions, particularly phase separation processes and the conformational properties of polymers in solution. His work includes foundational studies on spinodal decomposition and scaling laws in polymer mixtures, as well as investigations into the static and dynamic properties of polystyrene in solvents near the θ condition. Later research extended into bioactive peptide design, particularly the role of aromatic amino acids in receptor activation, demonstrating a shift toward bioorganic applications. His lab has contributed significantly to understanding both fundamental polymer physics and structure-activity relationships in peptide signaling.
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Abstract Characteristic features of the liquid-liquid phase separation process in polymer systems are presented, followed by a concise review of existing studies on phase-separation kinetics in polymer solutions and mixtures. Brief discussions have been made on two selective topics in this field, i.e., applicability of Cahn's linearized theory for spinodal decomposition to polymer mixtures and the scaling law in the late stage of phase separation. Key Words: polymer mixturephase separationspinod
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStatic and Dynamical Properties of Polystyrene in trans-Decalin. 1. NBS 705 Standard Near θ ConditionsT. Nose and B. ChuCite this: Macromolecules 1979, 12, 4, 590–599Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/ma60070a010https://doi.org/10.1021/ma60070a010research-articleACS PublicationsRequest reuse permissionsArticle Views166Altmetric-Citations59LEARN
Abstract A novel driving scheme that enables displaying motion‐pictures on LCDs is proposed, and a prototype LCD has successfully been demonstrated with a fast response LC cell. In this driving scheme, scanning black stripes are inserted in displayed images so that impulsive emission like that of CRTs can be produced. It is found that the LCD has a markedly improved motion‐image quality compared with conventional LCDs.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStatic and Dynamical Properties of Polystyrene in trans-Decalin. 3. Polymer Dimensions in Dilute Solution in the Transition RegionT. Nose and B. ChuCite this: Macromolecules 1979, 12, 6, 1122–1129Publication Date (Print):November 1, 1979Publication History Published online1 May 2002Published inissue 1 November 1979https://pubs.acs.org/doi/10.1021/ma60072a023https://doi.org/10.1021/ma60072a023research-articleACS PublicationsRequest reuse permissionsArti
A small number of « guest » polymeric chains (index of polymerization N) are dissolved in a semidilute solution of a host polymer (index P, concentration Φ) which is itself in a good solvent; the radius of gyration Rg and the second virial coefficient A2 are studied on the basis of the thermal- and concentration-blob models. The renormalized excluded — volume parameter τ has the form τ(ΦP3ν-1, χ) where ν is the index for the N — dependence of Rg in a good solvent ( Rg ∼ Nν) and χ the interaction
Phenylalanine at position 2 of thrombin receptor-tethered ligand peptide (SFLLRNP) is crucially important for the activation of thrombin receptor. Its substitution by para-fluorophenylalanine [(p-F)Phe] enhanced several times the activity in human epithelial-like SH-EP cells [Nose et al. (1993) Biochem. Biophys. Res. Commun. 193, 694-699]. To clarify the interaction mode of Phe-2-phenyl in receptor activation, a series of analogs having chemical modifications on the benzene ring of Phe-2 were sy
Elastin-like peptides (ELPs) are distinct, repetitive, hydrophobic sequences, such as (VPGVG) <sub>n</sub>, that exhibit coacervation, the property of reversible, temperature-dependent self-association and dissociation. ELPs can be found in elastin and have been developed as new scaffold biomaterials. However, the detailed relationship between their amino acid sequences and coacervation properties remains obscure because of the structural flexibility of ELPs. In this study, we synthesized a nove
Abstract Translational diffusion and internal motion have been observed by dynamic light scattering of optically labeled single chains of polystyrene (PS) in a semidilute solution of poly(methyl methacrylate) and benzene for the case in which the dimension R g of the PS chain is comparable to the correlation length of the matrix solution. The molecular weight M w dependence of the hydrodynamic radius R h is expressed as R h ∼ M , while R h ∼ M in pure benzene. The average linewidth Γ for interna
Halogenation of organic compounds is one the most important transformations in chemical synthesis and is used for the production of various industrial products. A variety of halogenated bisphenol analogs have recently been developed and are used as alternatives to bisphenol A (BPA), which is a raw material of polycarbonate that has adverse effects in animals. However, limited information is available on the potential toxicity of the halogenated BPA analogs. In the present study, to assess the la
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