The University of Osaka · Medicine
Professor Takeshi Noda's research lab focuses on the molecular mechanisms underlying autophagy, particularly the regulation of autophagosome formation and the signaling pathways that control this essential cellular degradation process. The lab investigates key regulators such as the TOR kinase and the VPS34-PI3K complex, with a special emphasis on the role of Atg14L in organizing autophagic membranes at the endoplasmic reticulum. By studying both yeast and mammalian systems, the lab aims to elucidate how cells switch between selective and bulk degradation pathways in response to environmental cues like nutrient availability.
Figures are computed from collected data and may differ slightly.
Autophagy is a bulk protein degradation process that is induced by starvation. The control mechanism for induction of autophagy is not well understood. We found that Tor, a phosphatidylinositol kinase homologue, is involved in the control of autophagy in the yeast, Saccharomyces cerevisiae. When rapamycin, an inhibitor of Tor function, is added, autophagy is induced even in cells growing in nutrient-rich medium. A temperature-sensitive tor mutant also leads to induction of autophagy at a nonperm
Autophagy is a catabolic process that allows cells to digest their cytoplasmic constituents via autophagosome formation and lysosomal degradation. Recently, an autophagy-specific phosphatidylinositol 3-kinase (PI3-kinase) complex, consisting of hVps34, hVps15, Beclin-1, and Atg14L, has been identified in mammalian cells. Atg14L is specific to this autophagy complex and localizes to the endoplasmic reticulum (ER). Knockdown of Atg14L leads to the disappearance of the DFCP1-positive omegasome, whi
In nutrient-rich, vegetative conditions, the yeast Saccharomyces cerevisiae transports a resident protease, aminopeptidase I (API), to the vacuole by the cytoplasm to vacuole targeting (Cvt) pathway, thus contributing to the degradative capacity of this organelle. When cells subsequently encounter starvation conditions, the machinery that recruited precursor API (prAPI) also sequesters bulk cytosol for delivery, breakdown, and recycling in the vacuole by the autophagy pathway. Each of these over
In this study, we propose a process framework for understanding the evolution of intraindustry firm heterogeneity, drawing on a longitudinal study of the development of the cellular telephone servi...
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