Nagoya University · Medicine
Professor Takuya Ishikawa's research lab specializes in advanced endoscopic diagnostics and pancreatic disease pathology, with a strong focus on improving the accuracy and safety of tissue diagnosis in autoimmune pancreatitis (AIP) and other pancreatic disorders. The lab pioneers the application of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) using innovative needles like the 22-gauge Franseen needle, aiming to enhance histological diagnosis and reduce reliance on serological markers. A key innovation involves integrating artificial intelligence—particularly deep learning and contrastive learning—into the analysis of EUS-FNB specimens to support real-time, objective diagnostic evaluation. The lab also investigates metabolic regulation in skeletal muscle, particularly the role of branched-chain amino acids (BCAAs) in mTORC1 signaling and protein metabolism under varying dietary conditions.
Figures are computed from collected data and may differ slightly.
EUS-FNA is useful in the differentiation of type 1 and type 2 AIP, particularly in seronegative cases.
EUS-FNB with a 22-gauge Franseen needle demonstrated favorable detection rates which would be clinically beneficial for the histological diagnosis of AIP.
Given its guaranteed ability to obtain core specimens and comparable safety, and although the risk of bleeding should be kept in mind, EUS-FNB using a Franseen needle is likely to become a standard procedure for obtaining pancreatic tissue in the near future.
We aimed to develop a new artificial intelligence (AI)-based method for evaluating endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) specimens in pancreatic diseases using deep learning and contrastive learning. We analysed a total of 173 specimens from 96 patients who underwent EUS-FNB with a 22 G Franseen needle for pancreatic diseases. In the initial study, the deep learning method based on stereomicroscopic images of 98 EUS-FNB specimens from 63 patients showed an accuracy of 71.8% f
Branched-chain amino acids (BCAAs) are essential amino acids for mammals and play key roles in the regulation of protein metabolism. However, the effect of BCAA deficiency on protein metabolism in skeletal muscle in vivo remains unclear. Here we generated mice with lower BCAA concentrations by specifically accelerating BCAA catabolism in skeletal muscle and heart (BDK-mKO mice). The mice appeared to be healthy without any obvious defects when fed a protein-rich diet; however, bolus ingestion of
Autoimmune pancreatitis patients show a high prevalence of peripancreatic vascular involvements. Thus, patients with vascular involvements are suitable candidates for steroid therapy with evaluation of its potential merits and demerits, even if they are asymptomatic.
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