Kyushu University · Medicine
Tomoharu Yoshizumi 교수의 연구실은 간세포암화(hepatocellular carcinoma, HCC) 환자의 수술 예후를 예측하고 개선하기 위한 임상기반 연구를 중심으로 전개되고 있습니다. 특히 혈액염색체지표(NLR), 근육량 감소(sarcopenia), 소형간이식 graft의 위험도 등 예후 예측 지표와 이식 성과 향상 전략을 다루며, 특히 생존율과 재발률에 영향을 미치는 생물학적 및 임상적 요인을 체계적으로 분석하고 있습니다. 또한, 살아있는 기증자 간이식(LDLT)에서 기증자 안전성과 수혜자 예후의 극적 균형을 확보하기 위한 다학제적 접근을 지속하고 있습니다.
Figures are computed from collected data and may differ slightly.
Our results show that NLR is an independent predictor of survival after hepatectomy in patients with HCC. Accumulation of tumor-associated macrophages in the tumor is associated with a high NLR.
Small-for-size (SFS) graft syndrome is one of the major causes of graft loss in living donor liver transplantation (LDLT). We examined whether splenectomy is beneficial for overcoming SFS graft syndrome in LDLT. The patients were classified into two groups: the Sp (-) group (n=69), in which splenectomy was not performed, and the Sp (+) group (n=44), in which it was. The incidence of SFS graft syndrome was investigated. Risk factors of SFS graft syndrome were identified by univariate- and multiva
This retrospective analysis revealed that sarcopenia was predictive of worse overall survival and recurrence-free survival after hepatectomy in patients 70 years of age and older with HCC.
LDLT should not be performed for patients who have both independent risk factors after any treatments for HCC.
Donor safety is the priority when performing a living donor adult liver transplantation (LDALT). We herein present our findings using left-lobe graft in LDALT. Data on 119 recipients who underwent the LDALT, and on 119 donors who underwent extended left lobectomy were reviewed. The recipients were divided into groups above (n = 19) and below (n = 100) 50 years of donor age, into groups above (n = 63) and below (n = 56) 40% of graft size (graft volume/standard liver volume, GV/SLV), and above (n
Sarcopenia can be defined by the difference between measured data and calculated data using our new formulae.
No reliable model for predicting early graft function and patient survival after living donor liver transplantation (LDLT) exists. The aim of this study was to establish a new formula for predicting early graft function and prognosis using technetium-99m galactosyl-human serum albumin (Tc-GSA) liver scintigraphy. The ratio of the hepatic uptake ratio of Tc-GSA to the clearance index of Tc-GSA (LHL/HH) was determined 7 days after LDLT. There were 22 patients with a ratio greater than 1.3 and 6 pa
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