Kyoto University · Medicine
Professor Tomohisa Okada's research lab specializes in cerebrovascular and neurological disorders, with a focus on the pathophysiology of cerebral vasospasm, intracranial arteriovenous malformations (AVMs), and the neurochemical basis of chronic fatigue syndrome. The lab employs advanced neuroimaging techniques such as diffusion tensor imaging (DTI) fiber tractography to assess structural brain changes, alongside experimental animal models to investigate vascular and neural mechanisms. Their work bridges clinical neurology with experimental pathology, emphasizing the impact of blood breakdown products and inflammatory cells on vascular remodeling and neural circuit integrity.
Figures are computed from collected data and may differ slightly.
These results are consistent with previous reports of an abnormal distribution of acetyl-L-carnitine uptake, which is one of the biochemical markers of chronic fatigue syndrome, in the prefrontal cortex. Thus, the prefrontal cortex might be an important element of the neural system that regulates sensations of fatigue.
A new animal model for vasospasm using rat femoral artery has been developed. Whole blood, washed erythrocytes, or leukocytes in platelet-rich plasma were selectively applied to the adventitial surface of the femoral artery for 7 days in 15 rats, after which the vessels were perfusion-fixed and examined by light and transmission electron microscopy and immunohistochemistry. As compared with matched control arteries, there was a prominent reduction in luminal cross-sectional area after 7 days in
<b>BACKGROUND AND PURPOSE:</b> We hypothesized that diffusion tensor fiber tractography would be affected by intracranial arteriovenous malformation (AVM). The purpose of the present study was to evaluate the influence of intracranial AVM on corticospinal tract and optic radiation tractography. <b>MATERIALS AND METHODS:</b> The subject group comprised 34 patients with untreated intracranial AVM. Hemorrhage was present in 13 patients and absent in 21 patients. Perinidal fractional anisotropy (FA)
A new animal model for vasospasm using rat femoral artery has been developed. Whole blood, washed erythrocytes, or leukocytes in platelet-rich plasma were selectively applied to the adventitial surface of the femoral artery for 7 days in 15 rats, after which the vessels were perfusion-fixed and examined by light and transmission electron microscopy and immunohistochemistry. As compared with matched control arteries, there was a prominent reduction in luminal cross-sectional area after 7 days in
Open papers in the app to read, cite, and organize with AI.
