Nagoya University · Medicine
Professor Tomomi Kotani's research lab focuses on the molecular mechanisms underlying placental development and pregnancy complications, particularly preeclampsia. Her team investigates transcriptional regulators such as AP-2alpha and AP-2gamma in extravillous trophoblasts, exploring their roles in trophoblast migration and invasion. The lab also examines the impact of maternal mental health on perinatal outcomes, especially in well-controlled psychiatric conditions. These studies aim to uncover key regulatory pathways in placental function and improve maternal-fetal health.
Figures are computed from collected data and may differ slightly.
The reduced migration/invasion of extravillous trophoblasts (EVTs) is a key feature of the genesis of preeclampsia. We and others previously reported that transcriptional factors activator protein-2 (AP-2) alpha and AP-2gamma act as suppressors of tumor invasion. The present study examined the expressions of AP-2alpha and AP-2gamma in preeclamptic placenta vs. control placenta and investigated their effect on the function of EVTs. The expressions of AP-2alpha and AP-2gamma were elevated in the p
A trend towards a lower birth weight and shorter gestational age was observed in Japanese women with well-controlled mental disorders, but the effect of well-controlled mental disorders on the perinatal outcome was minimal.
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